The potential of cinnamon to reduce blood glucose levels in patients with type 2 diabetes and insulin resistance
The potential of cinnamon to reduce blood glucose levels in patients with type 2 diabetes and insulin resistance
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DOI：
10.1111/j.1463-1326.2009.01094.x
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发表时间：
2009-12-01
影响因子：
5.8
通讯作者：
Tsiami, A.
中科院分区：
文献类型：
--
作者：
Kirkham, S.;Akilen, R.;Tsiami, A.
肉桂作为一种抗糖尿病的香料有着悠久的历史，但涉及肉桂补充剂的试验产生了相反的结果。本综述的目的是检查肉桂的随机对照临床试验的结果，并评估糖尿病患者和胰岛素抵抗患者的治疗潜力，特别是降低血糖水平和抑制蛋白质糖化的能力。2003年1月至2008年7月进行了一项使用肉桂或肉桂的安慰剂对照体内临床试验。结果5项2型糖尿病和3项非糖尿病研究（总N = 311）符合条件。其中两项糖尿病研究显示空腹血糖（FBG）显著降低18-29%和10.3%（p < 0.05），一项非糖尿病试验报告与安慰剂相比FBG降低8.4%（p < 0.01），另一项使用口服葡萄糖耐量试验显示葡萄糖反应显著降低（p < 0.05）。三个糖尿病研究报告没有显着result. ConclusionsWhile明确的结论不能得出关于使用肉桂作为抗糖尿病治疗，它确实具有抗高血压的性质和潜力，以减少餐后血糖水平。需要进一步的研究来证实基线FBG和血糖降低之间可能的相关性，并评估肉桂补充剂减少致病性糖尿病并发症的潜力。
AimCinnamon has a long history as an antidiabetic spice, but trials involving cinnamon supplementation have produced contrasting results. The aim of this review was to examine the results of randomized controlled clinical trials of cinnamon and evaluate the therapeutic potential amongst patients with diabetes and insulin-resistant patients, particularly the ability to reduce blood glucose levels and inhibit protein glycation.MethodsA systematic electronic literature search using the medical subject headings 'cinnamon' and 'blood glucose' was carried out to include randomized, placebo-controlled in vivo clinical trials using Cinnamomum verum or Cinnamomum cassia conducted between January 2003 and July 2008.ResultsFive type 2 diabetic and three non-diabetic studies (total N = 311) were eligible. Two of the diabetic studies illustrated significant fasting blood glucose (FBG) reductions of 18-29% and 10.3% (p < 0.05), supported by one non-diabetic trial reporting an 8.4% FBG reduction (p < 0.01) vs. placebo, and another illustrating significant reductions in glucose response using oral glucose tolerance tests (p < 0.05). Three diabetic studies reported no significant results.ConclusionsWhilst definitive conclusions cannot be drawn regarding the use of cinnamon as an antidiabetic therapy, it does possess antihyperglycaemic properties and potential to reduce postprandial blood glucose levels. Further research is required to confirm a possible correlation between baseline FBG and blood glucose reduction and to assess the potential to reduce pathogenic diabetic complications with cinnamon supplementation.