IFN-alpha expression and antiviral effects are subtype and cell type specific in the cardiac response to viral infection.
IFN-alpha expression and antiviral effects are subtype and cell type specific in the cardiac response to viral infection.
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IFN-α 表达和抗病毒作用在心脏对病毒感染的反应中具有亚型和细胞类型特异性。
DOI：
10.1016/j.virol.2009.10.013
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发表时间：
2010-01-05
期刊：
影响因子：
3.7
通讯作者：
Sherry, Barbara
中科院分区：
文献类型：
--
作者：
Li, Lianna;Sherry, Barbara
The interferon-β (IFN-β) response is critical for protection against viral myocarditis in several mouse models, and IFN-α or -β treatment is beneficial against human viral myocarditis. The IFN-β response in cardiac myocytes and cardiac fibroblasts forms an integrated network for organ protection, however the different IFN-α subtypes have not been studied in cardiac cells. We developed a quantitative RT-PCR assay that distinguishes between thirteen highly conserved IFN-α subtypes, and found that reovirus T3D induces five IFN-α subtypes in primary cardiac myocyte and fibroblast cultures: IFN-α1, -α2, -α4, -α5, and -α8/6. Murine IFN-α1, -α2, -α4, or -α5 treatment induced IRF7 and ISG56 and inhibited reovirus T3D replication in both cell types. This first investigation of IFN-α subtypes in cardiac cells for any virus demonstrates that IFN-α is induced in cardiac cells, that it is both subtype- and cell type-specific, and that it is likely important in the antiviral cardiac response.
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影响因子：
6.4
作者：
Cull, VS;Bartlett, EJ;James, CM
通讯作者：
James, CM
影响因子：
5.6
作者：
Khabar, KSA;al-Haj, L;Williams, BRG
通讯作者：
Williams, BRG
影响因子：
5.3
作者：
Genin, Pierre;Lin, Rongtuan;Civas, Ahmet
通讯作者：
Civas, Ahmet
DOI：
10.1006/bbrc.2001.5159
发表时间：
2001-07-13
影响因子：
3.1
作者：
Hata, N;Sato, M;Taniguchi, T
通讯作者：
Taniguchi, T
影响因子：
5.5
作者：
Izaguirre, A;Barnes, BJ;Fitzgerald-Bocarsly, P
通讯作者：
Fitzgerald-Bocarsly, P