AVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performance.
AVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performance.
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AVPR1A和SLC6A4基因多态性与创意舞蹈表演有关。
DOI：
10.1371/journal.pgen.0010042
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发表时间：
2005-09
期刊：
影响因子：
4.5
通讯作者：
Ebstein, RP
中科院分区：
文献类型：
--
作者：
Bachner-Melman, R;Dina, C;Zohar, AH;Constantini, N;Lerer, E;Hoch, S;Sella, S;Nemanov, L;Gritsenko, I;Lichtenberg, P;Granot, R;Ebstein, RP
舞蹈与音乐密不可分，很可能起源于智人的诞生，纵观我们的历史，舞蹈在所有社会中都得到了普遍的实践。我们假设，不同的人在能力、倾向和跳舞需求上存在差异，这可能部分基于常见基因多态的差异。识别这些差异可能有助于理解人类最普遍、最吸引人的行为特征之一--舞蹈的神经生物学基础。在目前的研究中，对85名正在表演的舞者及其父母进行了5-羟色胺转运体(SLC6A4：启动子区域HTTLPR和内含子2 VNTR)和精氨酸加压素受体1a(AVPR1a：启动子微卫星RS1和RS3)的基因分型。我们还对91名竞技运动员和一组非舞蹈者/非运动员(来自414个家庭的872名受试者)进行了基因分型。舞者在TelLegen吸入量表上得分更高，这是一份与灵性和意识变化呈正相关的问卷，以及克隆宁格三维人格问卷中的奖励依赖因素，这是一种衡量社交需求和沟通开放性的指标。AVPR1a单倍型频率(rs1和rs3)在使用非阶段性程序包的舞者和运动员之间观察到非常显著的差异，特别是当同时存在SLC6A4多态时(hTLPR和vntr)(COCAPHASE：似然比检验[LRS]=89.23，P=0.000044)。当舞蹈者与非舞蹈者/非运动员进行比较时，也得到了类似的结果(同期：LRS=92.76，P=0.000024)。这些结果得到了基于家庭的稳健测试的证实(Tdt阶段：LRS=46.64，p=0.010)。Tdt相：LRS=250.44，P=0.047；SLC6A4单倍型：Qtdt相：卡方=2.363，p=0.018；同样，三维人格问卷奖励依赖分数与AVPR1a RS1显著相关(卡方=20.16，p=0.01)。双基因座分析(rs1和rs3以HTTLPR和VntR为条件)具有极显著意义(LRS=162.95，p=0.001)。AVPR1a基因中的启动子重复区域已经被有力地证明在塑造许多脊椎动物的一系列社会行为方面发挥作用，最近在人类中也是如此。此外，在一些人类研究中，5-羟色胺能神经传递似乎调节了人类的宗教和精神体验。因此，我们假设AVPR1a和SLC6A4之间的联系反映了舞蹈表型的社会交流、求爱和精神方面，而不是这种复杂表型的其他方面，如感觉运动整合。舞蹈与音乐密不可分，其起源很可能与智人的诞生相近。作者假设，跳舞的能力、倾向和需求存在差异，这可能是基于常见基因多态的差异。找出这些差异可能有助于理解舞蹈的神经生物学基础。5-羟色胺转运体和精氨酸加压素受体1a基因的变异在表演者、精英运动员和非运动员/非舞者中被检测。5-羟色胺转运体调节5-羟色胺的水平，5-羟色胺是一种有助于精神体验的大脑递质。许多动物研究表明，加压素受体可以调节社交和联系行为。值得注意的是，舞者在TelLegen吸入量表上得分很高，这是一种与灵性相关的因素，以及Cloninger三维人格问卷中的回报依赖因素，这是一种衡量同理心、社交沟通和社交需求的指标。当舞蹈者与运动员以及非舞蹈者/非运动员进行比较时，这两个基因的等位基因频率都有显著差异。这两个基因还与TelLegen吸收量表和三维人格问卷奖励依赖的分数有关，这表明这些基因与舞蹈之间的联系是由反映舞蹈表型的社交、求爱和精神方面的个性因素介导的。
Dancing, which is integrally related to music, likely has its origins close to the birth of Homo sapiens, and throughout our history, dancing has been universally practiced in all societies. We hypothesized that there are differences among individuals in aptitude, propensity, and need for dancing that may partially be based on differences in common genetic polymorphisms. Identifying such differences may lead to an understanding of the neurobiological basis of one of mankind's most universal and appealing behavioral traits—dancing. In the current study, 85 current performing dancers and their parents were genotyped for the serotonin transporter (SLC6A4: promoter region HTTLPR and intron 2 VNTR) and the arginine vasopressin receptor 1a (AVPR1a: promoter microsatellites RS1 and RS3). We also genotyped 91 competitive athletes and a group of nondancers/nonathletes (n = 872 subjects from 414 families). Dancers scored higher on the Tellegen Absorption Scale, a questionnaire that correlates positively with spirituality and altered states of consciousness, as well as the Reward Dependence factor in Cloninger's Tridimensional Personality Questionnaire, a measure of need for social contact and openness to communication. Highly significant differences in AVPR1a haplotype frequencies (RS1 and RS3), especially when conditional on both SLC6A4 polymorphisms (HTTLPR and VNTR), were observed between dancers and athletes using the UNPHASED program package (Cocaphase: likelihood ratio test [LRS] = 89.23, p = 0.000044). Similar results were obtained when dancers were compared to nondancers/nonathletes (Cocaphase: LRS = 92.76, p = 0.000024). These results were confirmed using a robust family-based test (Tdtphase: LRS = 46.64, p = 0.010). Association was also observed between Tellegen Absorption Scale scores and AVPR1a (Qtdtphase: global chi-square = 26.53, p = 0.047), SLC6A4 haplotypes (Qtdtphase: chi-square = 2.363, p = 0.018), and AVPR1a conditional on SCL6A4 (Tdtphase: LRS = 250.44, p = 0.011). Similarly, significant association was observed between Tridimensional Personality Questionnaire Reward Dependence scores and AVPR1a RS1 (chi-square = 20.16, p = 0.01). Two-locus analysis (RS1 and RS3 conditional on HTTLPR and VNTR) was highly significant (LRS = 162.95, p = 0.001). Promoter repeat regions in the AVPR1a gene have been robustly demonstrated to play a role in molding a range of social behaviors in many vertebrates and, more recently, in humans. Additionally, serotonergic neurotransmission in some human studies appears to mediate human religious and spiritual experiences. We therefore hypothesize that the association between AVPR1a and SLC6A4 reflects the social communication, courtship, and spiritual facets of the dancing phenotype rather than other aspects of this complex phenotype, such as sensorimotor integration. Dancing, integrally related to music, likely has its origins close to the birth of Homo sapiens. The authors hypothesized that there are differences in aptitude, propensity, and need for dancing that may be based on differences in common genetic polymorphisms. Identifying such differences may lead to an understanding of the neurobiological basis of dancing. Variants of the serotonin transporter and the arginine vasopressin receptor 1a genes were examined in performing dancers, elite athletes, and nonathletes/nondancers. The serotonin transporter regulates the level of serotonin, a brain transmitter that contributes to spiritual experience. The vasopressin receptor has been shown in many animal studies to modulate social communication and affiliative behaviors. Notably, dancers scored high on the Tellegen Absorption Scale, a correlate of spirituality, and the Reward Dependence factor in Cloninger's Tridimensional Personality Questionnaire, a measure of empathy, social communication, and need for social contact. Significant differences were observed in allele frequencies for both genes when dancers were compared to athletes as well as to nondancers/nonathletes. These two genes were also associated with scores on the Tellegen Absorption Scale and Tridimensional Personality Questionnaire Reward Dependence, suggesting that the association between these genes and dance is mediated by personality factors reflecting the social communication, courtship, and spiritual facets of the dancing phenotype.
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DOI：
10.1073/pnas.111134598
发表时间：
2001-06-05
影响因子：
11.1
作者：
Egan, MF;Goldberg, TE;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
64.8
作者：
Bowler, JM;Johnston, H;Spooner, NA
通讯作者：
Spooner, NA
影响因子：
3.5
作者：
Goodson, JL
通讯作者：
Goodson, JL
影响因子：
56.9
作者：
Caspi, A;McClay, J;Poulton, R
通讯作者：
Poulton, R
影响因子：
2.1
作者：
Dudbridge, F
通讯作者：
Dudbridge, F