Tubulointerstitial macrophage infiltration in a patient with hypokalemic nephropathy and primary Sjögren's syndrome.
Tubulointerstitial macrophage infiltration in a patient with hypokalemic nephropathy and primary Sjögren's syndrome.
复制标题
低钾肾病和原发性干燥综合征患者的肾小管间质巨噬细胞浸润。
DOI：
10.5414/cnp64387
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发表时间：
2005
影响因子：
1.1
通讯作者：
Y. Saito
中科院分区：
文献类型：
--
作者：
K. Harada;Y. Akai;M. Iwano;K. Nakatani;T. Nishino;T. Fujimoto;H. Shiiki;Y. Saito
我们报告一例与原发性干燥综合征（SS）相关的低钾性肾病病例。患者出现继发于远端肾小管酸中毒（RTA）的严重且持续的低钾血症。肾活检显示肾小管变性、明显的间质纤维化和强烈的巨噬细胞浸润。据报道，低钾血症在实验动物模型中会诱导巨噬细胞浸润，但在人类中则不然。这是首次报道 SS 相关低钾性肾病患者出现强烈的肾小管间质巨噬细胞浸润。
We report a case of hypokalemic nephropathy associated with primary Sjögren's syndrome (SS). The patient presented with profound and persistent hypokalemia secondary to distal renal tubular acidosis (RTA). A renal biopsy exhibited tubular degeneration, marked interstitial fibrosis and intense macrophage infiltration. Hypokalemia has been reported to induce macrophage infiltration in experimental animal models but not in humans. This is the first report of intense tubulointerstitial macrophage infiltration in a patient with hypokalemic nephropathy associated with SS.