Heterogeneity Signs on Noncontrast Computed Tomography Predict Hematoma Expansion after Intracerebral Hemorrhage: A Meta-Analysis.
Heterogeneity Signs on Noncontrast Computed Tomography Predict Hematoma Expansion after Intracerebral Hemorrhage: A Meta-Analysis.
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DOI：
10.1155/2018/6038193
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发表时间：
2018
影响因子：
--
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Zhang D;Chen J;Xue Q;Du B;Li Y;Chen T;Jiang Y;Hou L;Dong Y;Wang J
血肿扩大（HE）与脑出血（ICH）后的临床恶化有关，非造影计算机断层扫描（NCCT）体征被认为是HE的预测因子，但结论不一致。我们的目的是澄清NCCT异质性体征与HE的相关性，通过相关研究的荟萃分析。 检索PubMed、Embase和科克伦图书馆中探索NCCT异质性体征（低密度、混合密度、漩涡征、混合征和黑洞征）与HE之间关系的合格研究。不良结局和死亡率被认为是次要结局。以比值比（OR）及其95%可信区间（CI）作为效应量，采用随机效应模型进行组合。 纳入了14项研究，涉及3240名参与者和435名HE。总结结果显示异质性体征与HE（OR，5.17; 95% CI，3.72-7.19，P < 0.001）、不良结局（OR，3.60; 95% CI，1.98-6.54，P < 0.001）和死亡率（OR，4.64; 95%，2.96-7.27，P < 0.001）具有统计学显著相关性。 我们的研究结果表明，NCCT上的血肿异质性体征与ICH中HE风险增加、预后不良和死亡率呈正相关。
Hematoma expansion (HE) is related to clinical deterioration after intracerebral hemorrhage (ICH) and noncontrast computed tomography (NCCT) signs are indicated as predictors for HE but with inconsistent conclusions. We aim to clarify the correlations of NCCT heterogeneity signs with HE by meta-analysis of related studies. PubMed, Embase, and Cochrane library were searched for eligible studies exploring the relationships between NCCT heterogeneity signs (hypodensity, mixed density, swirl sign, blend sign, and black hole sign) and HE. Poor outcome and mortality were considered as secondary outcomes. Odds ratio (OR) and its 95% confidence intervals (CIs) were selected as the effect size and combined using random effects model. Fourteen studies were included, involving 3240 participants and 435 HEs. The summary results suggested statistically significant correlations of heterogeneity signs with HE (OR, 5.17; 95% CI, 3.72–7.19, P < 0.001), poor outcome (OR, 3.60; 95% CI, 1.98–6.54, P < 0.001), and mortality (OR, 4.64; 95%, 2.96–7.27, P < 0.001). Our findings suggested that hematoma heterogeneity signs on NCCT were positively associated with the increased risk of HE, poor outcome, and mortality rate in ICH.
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影响因子：
1.9
作者：
Subramanian, SK;Roszler, MH;Michael, DB
通讯作者：
Michael, DB
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
29
作者：
Boulouis G;Morotti A;Brouwers HB;Charidimou A;Jessel MJ;Auriel E;Pontes-Neto O;Ayres A;Vashkevich A;Schwab KM;Rosand J;Viswanathan A;Gurol ME;Greenberg SM;Goldstein JN
通讯作者：
Goldstein JN
影响因子：
8.3
作者：
Barras, Christen D.;Tress, Brian M.;Davis, Stephen M.
通讯作者：
Davis, Stephen M.
影响因子：
8.3
作者：
Blacquiere, Dylan;Demchuk, Andrew M.;Dowlatshahi, Dar
通讯作者：
Dowlatshahi, Dar