High levels of colicin resistance in Escherichia coli
High levels of colicin resistance in Escherichia coli
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DOI：
10.1111/j.1558-5646.1998.tb02008.x
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发表时间：
1998-10-01
期刊：
影响因子：
3.3
通讯作者：
Riley, MA
中科院分区：
文献类型：
--
作者：
Feldgarden, M;Riley, MA
Colicins是一种质粒编码的抗生素，由大肠杆菌和其他相关物种产生并杀死。大肠埃希菌产生粘连素的频率较高，平均有30%的菌株产生粘连素。对一组72株大肠杆菌(EcoR组)的初步观察表明，对Colicin杀灭的耐药性也普遍存在，超过70%的菌株对一种或多种Colicins具有耐药性。为了确定耐药性是否是大肠杆菌的共同特征，对另外三个菌株进行了调查。在每个样本中，粘菌素的产量水平都很高(15%到50%的菌株生产粘菌素)。对粘连素的耐药性水平更高，大多数菌株对10种以上的粘连素耐药。对137名非E类人群进行调查。大肠埃希氏菌显示出更高的抗药性。我们讨论了一种机制(多效性)，它可能导致如此高水平的结肠素生产和结肠素耐药性共存。
Colicins are plasmid-encoded antibiotics that are produced by and kill Escherichia coli and other related species. The frequency of colicinogeny is high, on average 30% of E. coli isolates produce colicins. Initial observations from one collection of 72 strains of E. coli (the ECOR collection) suggest that resistance to colicin killing is also ubiquitous, with over 70% of strains resistant to one or more colicins. To determine whether resistance is a common trait in E. coli, three additional strain collections were surveyed. In each of these collections levels of colicin production were high (from 15 to 50% of the strains produce colicins). Levels of colicin resistance were even higher, with most strains resistant to over 10 colicins. A survey of 137 non-E. coli isolates revealed even higher levels of resistance. We discuss a mechanism (pleiotropy) that could result in the co-occurrence of such high levels of colicin production and colicin resistance.