The ectodermal dysplasia receptor represses the Lef-1/beta-catenin-dependent transcription independent of NF-kappaB activation.
The ectodermal dysplasia receptor represses the Lef-1/beta-catenin-dependent transcription independent of NF-kappaB activation.
复制标题
外胚层发育不良受体抑制 Lef-1/β-catenin 依赖性转录，与 NF-kappaB 激活无关。
DOI：
10.1016/j.bbrc.2004.01.025
复制
发表时间：
2004
影响因子：
3.1
通讯作者：
Chaudhary,PreetM
中科院分区：
文献类型：
--
作者：
Shindo,Masahisa;Chaudhary,PreetM
EDAR plays a key role in the process of ectodermal differentiation via activation of the NF-κB pathway. We present evidence that EDAR also represses Lef-1/β-catenin-dependent transcription and this ability is defective in EDAR mutants associated with anhidrotic ectodermal dysplasia. While IKK1/IKKα and IKK2/IKKβ are required for EDAR-induced NF-κB activation, they are dispensable for its ability to repress Lef-1/β-catenin-dependent transcription. In contrast, NIK is not involved in EDAR-induced NF-κB activation or Lef-1/β-catenin transcriptional repression. As Lef-1/β-catenin pathway controls the expression of EDAR ligand, ectodysplasin-A (EDA), our results point to a negative feedback regulation of EDA–EDAR axis.
