Serum uric acid levels in patients with Parkinson's disease: Their relationship to treatment and disease duration
Serum uric acid levels in patients with Parkinson's disease: Their relationship to treatment and disease duration
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DOI：
10.1016/j.clineuro.2009.06.012
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发表时间：
2009-11-01
影响因子：
1.9
通讯作者：
Vassilopoulos, Demetrios
中科院分区：
文献类型：
--
作者：
Andreadou, Elisabeth;Nikolaou, Chryssoula;Vassilopoulos, Demetrios
有证据支持氧化应激在帕金森病（PD）中增加，并有助于多巴胺能神经元的变性。尿酸（UA）是血液和脑组织中的天然抗氧化剂，具有清除超氧阴离子、过氧亚硝酸根和羟自由基的作用。此外，低血浆尿酸（UA）水平与PD风险增加有关。目的：我们研究的目的是调查PD患者与年龄匹配的健康对照组相比的血清UA水平，以及它们与PD和药物治疗的几个临床参数的可能关系。患者和方法：我们检测了43例PD患者和47例健康志愿者的血清UA水平，年龄和性别匹配。UA水平与疾病的持续时间，严重程度和treatment.Results：低UA水平观察PD患者与对照组相比（p = 0.009）。年龄、体重指数（BMI）和BMI III评分对血清UA水平无显著影响，而性别对UA水平有显著影响（p < 0.000）。观察到UA与疾病持续时间（R-s =-0.397，p = 0.009）和每日左氯帕剂量（R-p =-0.498，p = 0.026）呈强且显著的负相关。这些关联对男性来说意义重大（R-s =-0.441，p = 0.04和R-s =-0.717，p = 0.03），但不适用于女性（R-s =-0.221，p = 0.337和R-s =-0.17，p = 0.966）。我们的研究结果表明，有可能增加消费的UA作为一种清道夫在PD，可能提高多巴胺能药物治疗。鉴于UA的抗氧化特性，应研究其浓度的操纵以用于疾病的潜在治疗策略。(C)2009爱思唯尔有限公司版权所有。
There is evidence to support that oxidative stress is increased in Parkinson's disease (PD) and contributes to degeneration of dopaminergic neurons. Uric acid (UA), a natural antioxidant in blood and brain tissue, scavenging superoxide, peroxynitrite and hydroxyl radical, was found reduced in the serum of PD patients. In addition low plasma uric acid (UA) levels have been associated with an increased risk of PD.Objectives: The aim of our study was to investigate serum UA levels in PD patients compared with age-matched healthy controls and their possible relationship with several clinical parameters of PD and pharmaceutical treatment.Patients and methods: We measured serum UA levels in 43 PD patients and 47 healthy volunteers, age and sex-matched. UA levels were correlated with disease duration, severity and treatment.Results: Low UA levels were observed in PD patients compared with controls (p = 0.009). Age, Body Mass Index (BMI) and UPDRS III score did not significantly affect serum UA concentrations, whereas gender was found to contribute significantly to UA level (p < 0.000). Strong and significant inverse correlations of UA with disease duration (R-s = -0.397, p = 0.009) and daily levoclopa dosage (R-p = -0.498, p = 0.026) were observed. These associations were significant for men (R-s = -0.441, p = 0.04 and R-s = -0.717, p = 0.03 respectively), but not for women (R-s = -0.221, p = 0.337 and R-s = -0.17, p = 0.966 respectively).Conclusion: Our results suggest that there may be increased consumption of UA as a scavenger in PD, possibly heightened by dopaminergic drug treatment. Given the antioxidant properties of UA, manipulation of its concentrations should be investigated for potential therapeutic strategies of the disease. (C) 2009 Elsevier B.V. All rights reserved.