Bacteremia in autoimmune bullous disease patients undergoing double-filtration plasmapheresis.
Bacteremia in autoimmune bullous disease patients undergoing double-filtration plasmapheresis.
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接受双重过滤血浆置换术的自身免疫性大疱性疾病患者的菌血症。
DOI：
10.1080/09546634.2018.1525479
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
et al.
中科院分区：
文献类型：
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作者：
Ohata C;Koga H;Saruta H;et al.
背景：血浆置换是自身免疫性大疱病(AIBD)的治疗方案之一。目的：评价血浆置换过程中不良事件的发生率。方法：本研究收集了2007年至2016年库鲁姆大学医院收治的28例AIBD患者的42个疗程的双滤过血浆置换(DFPP)。结果：最常见的不良事件是菌血症(13/42个疗程，31.0%)，其次是皮下出血(1个疗程，2.4%)和导管部位脓肿(1个疗程，2.4%)。没有不良事件相关死亡的记录。在菌血症发生的分析中，菌血症组插管部位的侵蚀、中心静脉导管的使用和每疗程DFPP循环次数均显著多于非菌血症组(p分别为 .0474、0.0005和0.0035)。结论：虽然DFPP是一种较好的治疗方法，但在DFPP过程中可能出现的风险值得注意。我们相信，我们的结果可以应用于AIBD治疗中的其他血浆蛋白。
Background:Plasmapheresis is one of the treatment options for autoimmune bullous disease (AIBD).Objective:To evaluate the incidence of adverse events occurring during a course of plasmapheresis.Methods:This study enrolled 42 courses of double-filtration plasmapheresis (DFPP) from 28 patients with AIBD treated in Kurume University Hospital between 2007 and 2016. We examined the frequency of adverse events during the course of DFPP and associated features.Results:The most frequent adverse event was bacteremia (13 of 42 courses, 31.0%), followed by subcutaneous hemorrhage (1 course, 2.4%), and an abscess at the catheterization sites (1 course, 2.4%). No adverse event-related death was recorded. In the analysis of bacteremia occurrence, the erosion at the catheterization sites, the use of central venous catheter (CVC), and the number of DFPP cycles per course were significantly more or greater in the bacteremia group than in the non-bacteremia group (p= .0474, .0005, and .0035, respectively).Conclusions:Although DFPP is a good treatment option for AIBD, attention needs to be paid for the development of possible risks during a DFPP course. We believe that our results can be applied to other plasmaphereses in AIBD management.