Possible Contrast Media Reduction with Low keV Monoenergetic Images in the Detection of Focal Liver Lesions: A Dual-Energy CT Animal Study.
Possible Contrast Media Reduction with Low keV Monoenergetic Images in the Detection of Focal Liver Lesions: A Dual-Energy CT Animal Study.
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DOI：
10.1371/journal.pone.0133170
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Kim MJ
中科院分区：
文献类型：
--
作者：
Chung YE;You JS;Lee HJ;Lim JS;Lee HS;Baek SE;Kim MJ
探讨双能量CT减少造影剂（CM）在诊断多血供和少血供肝局灶性病变（FLL）中的可行性。机构动物护理和使用委员会批准了本研究。将VX 2肿瘤植入13只家兔的两个不同的肝脏节段中。2周后，分别用300（I300）、150（I150）和75 mg I/mL（I75）三种不同浓度的碘进行动脉期（AP）和门静脉期（PVP）增强扫描，每次间隔24 h。在140 kVp图像（I300作为参考标准）和单能图像（40 keV至140 keV）（I150和I75）中，测量肝脏、代表多血管肿瘤的VX 2肿瘤的多血管部分和代表少血管肿瘤的VX 2肿瘤的中央坏死区域的平均HU和标准差（SD）。计算FLL的对比度噪声比（CNR）以及I150和I75单能图像集与参考标准之间的CNR比（CNRratio）。对于多血管病变，CNR比在40 keV和70 keV图像与I150之间没有统计学差异，而CNR比在所有keV图像与I75中均显著低于1.0。对于少血管病变，在40 keV和80 keV之间，I 150和40 keV和70 keV之间，I 75的CNR比接近或高于1.0。使用双能量CT，在诊断多血供FLL时CM总量可能减半，在诊断少血供FLL时减少至四分之一，同时仍保留CNR。
To investigate the feasibility of dual-energy CT for contrast media (CM) reduction in the diagnosis of hypervascular and hypovascular focal liver lesions (FLL). The Institutional Animal Care and Use Committee approved this study. VX2 tumors were implanted in two different segments of the liver in 13 rabbits. After 2 weeks, two phase contrast enhanced CT scans including the arterial phase (AP) and portal-venous phase (PVP) were performed three times with 24-hour intervals with three different concentrations of iodine, 300 (I300), 150 (I150) and 75 mg I/mL (I75). The mean HU and standard deviation (SD) were measured in the liver, the hypervascular portion of the VX2 tumor which represented hypervascular tumors, and the central necrotic area of the VX2 tumor which represented hypovascular tumors in 140kVp images with I300 as a reference standard and in monoenergetic images (between 40keV and 140keV) with I150 and I75. The contrast-to-noise ratio (CNR) for FLLs and the ratio of the CNRs (CNRratio) between monoenergetic image sets with I150 and I75, and the reference standard were calculated. For hypervascular lesions, the CNRratio was not statistically different from 1.0 between 40keV and 70keV images with I150, whereas the CNRratio was significantly lower than 1.0 in all keV images with I75. For hypovascular lesions, the CNRratio was similar to or higher than 1.0 between 40keV and 80keV with I150 and between 40keV and 70keV with I75. With dual-energy CT, the total amount of CM might be halved in the diagnosis of hypervascular FLLs and reduced to one-fourth in the diagnosis of hypovascular FLLs, while still preserving CNRs.