Astrocyte and oligodendrocyte connexins of the glial syncytium in relation to astrocyte anatomical domains and spatial buffering.
Astrocyte and oligodendrocyte connexins of the glial syncytium in relation to astrocyte anatomical domains and spatial buffering.
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神经胶质合胞体的星形胶质细胞和少突胶质细胞连接蛋白与星形胶质细胞解剖结构域和空间缓冲的关系。
DOI：
10.1080/15419060390263191
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发表时间：
2003
影响因子：
--
通讯作者：
Rash,JohnE
中科院分区：
文献类型：
--
作者：
Nagy,JamesI;Rash,JohnE
星形细胞表达一组三个连接蛋白（Cx 26、Cx 30和Cx43），其包含在星形胶质细胞-星形胶质细胞（A/A）间隙连接中;少突胶质细胞表达不同的三种连接蛋白（Cx 29、Cx 32和Cx47），其包含在必然异型星形胶质细胞-少突胶质细胞（A/O）间隙连接的少突胶质细胞侧，并且在单个少突胶质细胞之间几乎没有间隙连接形成的超微结构证据。此外，Cx 29和Cx 32主要包含在髓鞘的更深处，它们在未压实的髓鞘部位形成自体间隙连接。大胶质细胞群中存在6种连接蛋白，揭示了潜在连接蛋白偶联伴侣的前所未有的复杂性，并限制了“泛胶质”合胞体内间隙连接细胞间通讯（GJIC）的部署。胶质细胞GJIC介导的空间缓冲的组织和调节的新的影响来自最近的观察存在单独的星形胶质细胞解剖结构域，只有狭窄的区域之间的重叠星形胶质细胞的过程域边界。因此，CNS中广泛的空间缓冲可能不是通过不同星形胶质细胞产生的众多过程连续发生的，而是通过细胞间偶联以更有序的方式从一个星形胶质细胞结构域到另一个星形胶质细胞结构域发生的，这种偶联仅发生在星形胶质细胞结构域之间重叠的有限区域，并通过每个结构域内发生的自体细胞偶联增强。
Astroctyes express a set of three connexins (Cx26, Cx30, and Cx43) that are contained in astrocyte-to-astrocyte (A/A) gap junctions; oligodendrocytes express a different set of three connexins (Cx29, Cx32, and Cx47) that are contained in the oligodendrocyte side of necessarily heterotypic astrocyte-to-oligodendrocyte (A/O) gap junctions, and there is little ultrastructural evidence for gap junction formation between individual oligodendrocytes. In addition, primarily Cx29 and Cx32 are contained deeper in myelin sheaths, where they form autologous gap junctions at sites of uncompacted myelin. The presence of six connexins in macroglial cell populations has revealed unprecedented complexity of potential connexin coupling partners, and with restricted deployment of gap junctional intercellular communication (GJIC) within the “pan-glial” syncytium. New implications for the organization and regulation of spatial buffering mediated by glial GJIC are derived from recent observations of the existence of separate astrocyte anatomical domains, with only narrow regions of overlap between astrocyte processes at domain borders. Thus, widespread spatial buffering in the CNS may occur not successively through a multitude of processes arising from different astrocytes, but rather in a more orderly fashion from one astrocyte domain to another via intercellular coupling that occurs only at restricted regions of overlap between astrocyte domains, augmented by autocellular coupling that occurs within each domain.