Comparison between free serum thyroxine levels, measured by analog and dialysis methods, in the presence of perfluorooctane sulfonate and perfluorooctanoate
Comparison between free serum thyroxine levels, measured by analog and dialysis methods, in the presence of perfluorooctane sulfonate and perfluorooctanoate
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DOI：
10.1016/j.reprotox.2011.04.002
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发表时间：
2012-07-01
影响因子：
3.3
通讯作者：
Fletcher, Tony
中科院分区：
文献类型：
--
作者：
Lopez-Espinosa, Maria-Jose;Fitz-Simon, Nicola;Fletcher, Tony
动物研究结果表明，游离甲状腺素 (FT4) 和全氟辛烷磺酸 (PFOS) 血清水平之间的负相关性（浓度远高于任何暴露人群报告的浓度）可能是由于用于测量 FT4 的模拟方法存在偏差。我们的目的是评估在 50 名具有典型美国血清 PFOS 浓度但较高 PFOA 浓度的成年人中，由于 PFOS 或全氟辛酸盐 (PFOA) 的存在，通过类似物和透析方法测量的人类血清 FT4 之间是否存在差异。平均模拟透析差异为 -0.02 (95% Cl = -0.06, 0.02)。对 PFOA 或 PFOS 血清浓度的 FT4 测量值之间的差异进行回归得到的斜率接近于零。目前的研究结果并未表明，在该人群的 PFOS 和 PFOA 浓度范围内，使用透析方法类似物会产生任何可观察到的偏差。 (C) 2011 Elsevier Inc. 保留所有权利。
Results from animal studies have shown that negative associations between serum levels of free thyroxine (FT4) and perfluorooctane sulfonate (PFOS) at concentrations much higher than those reported for any exposed population may be due to bias in analog methods used for measuring FT4. We aimed to assess if there is evidence of differences between human FT4 measurements in serum by an analog and a dialysis method due to the presence of PFOS or perfluorooctanoate (PFOA) in a population of 50 adults with typical US serum PFOS concentrations but higher PFOA concentrations. Mean analog-dialysis difference was -0.02 (95% Cl = -0.06, 0.02). Regressing the difference between FT4 measurements on either PFOA or PFOS serum concentrations yielded slopes close to zero. The present findings do not indicate any observable bias from the use of the analog with respect to the dialysis method, across the range of PFOS and PFOA concentrations in this population. (C) 2011 Elsevier Inc. All rights reserved.