Effect of longitudinal changes in visceral fat area and other anthropometric indices to the changes in metabolic risk factors in Japanese men: the Hitachi Health Study.
Effect of longitudinal changes in visceral fat area and other anthropometric indices to the changes in metabolic risk factors in Japanese men: the Hitachi Health Study.
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DOI：
10.2337/dc11-1320
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发表时间：
2012-05
期刊：
影响因子：
16.2
通讯作者：
Noda M
中科院分区：
文献类型：
--
作者：
Matsushita Y;Nakagawa T;Yamamoto S;Takahashi Y;Yokoyama T;Mizoue T;Noda M
内脏脂肪面积（VFA）和其他人体测量指标的纵向变化对代谢综合征危险因素的影响尚未研究。我们在一项针对日本男性的大规模研究中计算了与某些人体测量指数变化相关的代谢风险因素的变化。受试者是参加日立健康研究的 1,106 名男性，他们在 2004 年和 2007 年接受了计算机断层扫描检查。使用计算机断层扫描测量了 VFA、皮下脂肪面积 (SFA) 和腰围。我们研究了三年期间每个人体测量指数的纵向变化如何影响每个代谢风险因素的值。 3 年期间体重、SFA 和腰围的变化 (Δ) 强相关，而体重和 VFA 的变化弱相关。 VFA 的变化与代谢危险因素的变化相关，尤其是甘油三酯和 HDL 的变化；我们发现这些变化与Δ体重和Δ腰围无关。体重变化并不是 ΔVFA 的精确替代指标，随着时间的推移重复测量 VFA 是有用的。采用不增加 VFA 的生活方式对于预防代谢综合征非常重要。
The effects of longitudinal changes in the visceral fat area (VFA), and other anthropometric indices, on the risk factors of metabolic syndrome were not studied. We calculated the changes in metabolic risk factors in relation to changes in certain anthropometric indices in a large-scale study of Japanese men. The subjects were 1,106 men participating in the Hitachi Health Study who received a computed tomography examination in both 2004 and 2007. VFA, subcutaneous fat area (SFA), and waist circumference were measured using the computed tomography. We examined how longitudinal changes in each anthropometric index over a 3-year period influenced the value of each metabolic risk factor. Changes (∆) over a 3-year period in body weight, SFA, and waist circumference strongly correlated, while the changes in body weight and VFA were weakly correlated. Changes in the VFA were associated with changes in metabolic risk factors, especially changes in triglyceride and HDL; we found these changes to be independent of the ∆body weight and ∆waist circumference. Change in body weight is not a precise surrogate marker of ∆VFA, and repeated VFA measurements over time are useful. Adopting a lifestyle that does not increase the VFA is important in preventing metabolic syndrome.