Role of taurine in preventing acetaminophen-induced hepatic injury in the rat.
Role of taurine in preventing acetaminophen-induced hepatic injury in the rat.
复制标题
牛磺酸在预防对乙酰氨基酚诱导的大鼠肝损伤中的作用。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
D. Bouchier
中科院分区：
文献类型：
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作者：
Eoin Waters;Jiang;H. Redmond;Q. Wu;E. Kay;D. Bouchier
对乙酰氨基酚过量会导致人类和动物的急性肝损伤。本研究旨在探讨条件必需氨基酸牛磺酸在预防对乙酰氨基酚所致肝毒性中的潜在作用。对雄性Sprague-Dawley大鼠腹腔内给予对乙酰氨基酚（800 mg/kg）。牛磺酸（200 mg/kg）在对乙酰氨基酚注射前12 h、注射时和注射后1或2 h给药。对乙酰氨基酚处理增加了天冬氨酸转氨酶、丙氨酸转氨酶和碱性磷酸酶的血浆水平，并导致肝DNA断裂和肝细胞坏死。在对乙酰氨基酚给药前、给药同时或给药后1 h给予牛磺酸，可显著改善肝损伤，表现为肝细胞酶释放减少和肝细胞凋亡和坏死减弱，这与牛磺酸介导的肝脂质过氧化减弱相关。提示牛磺酸对醋氨酚所致肝损伤具有预防和治疗作用。
Acetaminophen overdose causes acute liver injury in both humans and animals. This study was designed to investigate the potential role of the conditionally essential amino acid taurine in preventing acetaminophen-induced hepatotoxicity. Male Sprague-Dawley rats were administered acetaminophen (800 mg/kg) intraperitoneally. Taurine (200 mg/kg) was given 12 h before, at the time of, and 1 or 2 h after acetaminophen injection. Acetaminophen treatment increased the plasma levels of aspartate transaminase, alanine aminotransferase, and alkaline phosphatase and caused hepatic DNA fragmentation and hepatocyte necrosis. Taurine administered before, simultaneously with, or 1 h after acetaminophen resulted in significant improvement in hepatic injury as represented by decrease of hepatocellular enzyme release and attenuation of hepatocyte apoptosis and necrosis, and this correlated with taurine-mediated attenuation of hepatic lipid peroxidation. These results indicate that taurine possesses prophylactic and therapeutic effects in acetaminophen-induced hepatic injury.