Significance of serum uric acid in pulmonary hypertension due to systemic sclerosis: a pilot study
Significance of serum uric acid in pulmonary hypertension due to systemic sclerosis: a pilot study
复制标题
DOI：
10.1007/s00296-010-1557-4
复制
发表时间：
2011-02-01
影响因子：
4
通讯作者：
Settas, Loukas
中科院分区：
文献类型：
--
作者：
Dimitroulas, Theodoros;Giannakoulas, Georgios;Settas, Loukas
系统性硬化症是一种结缔组织疾病，可导致肺动脉高压和/或左心室舒张功能障碍导致肺动脉压升高。肺动脉高压和心力衰竭患者的尿酸水平升高。我们的目的是研究SSc患者血清UA和肺动脉压以及功能能力之间的潜在关系。我们研究了66例患者（平均年龄57.7 ± 12.1岁，63名女性），表现为SSc。记录超声心动图、肺功能、6分钟步行试验（6 MWT）及血清尿酸水平。在24例（36%）患者中，通过超声心动图（肺动脉收缩压为千分之一40 mmHg）确定了PH的诊断。PH患者的UA血清水平高于非PH患者（5.1 +/- A 2.1 mg/dl vs. 4.2 +/- A 0.9 mg/dl，p = 0.04）。在PH患者中，UA值与SMWT距离呈负相关（r =-0.51，p = 0.01）。硬皮病PH患者血清UA值与功能能力成比例增加。前瞻性研究中的进一步调查将详细揭示UA在SSc PH患者中的病理生理学意义，并确定其作为疾病评估和监测的预后标志物的作用。
Systemic sclerosis is a connective tissue disease, which may lead to elevated pulmonary arterial pressure due to pulmonary arterial hypertension and/or left ventricular diastolic dysfunction. Uric acid (UA) has been shown to be elevated in patients with pulmonary hypertension (PH) and heart failure. We aimed to investigate the potent relationship between serum UA and pulmonary pressure as well as functional capacity in patients with SSc. We studied 66 patients (mean age 57.7 +/- A 12.1 years, 63 women), presenting with SSc. Systolic pulmonary artery pressure assessed by echocardiography, lung function tests, six-minute walk test (6MWT) and serum UA levels were recorded in all patients. In 24 (36%) patients, the diagnosis of PH was established by echocardiography (systolic pulmonary artery pressure a parts per thousand yen40 mmHg). Patients with PH had higher UA serum levels compared to patients without PH (5.1 +/- A 2.1 mg/dl vs. 4.2 +/- A 0.9 mg/dl, p = 0.04). Among patients with PH, UA values were inversely correlated with the SMWT distance (r = -0.51, p = 0.01). Serum UA values increased in proportion to the functional capacity in PH patients with scleroderma. Further investigations in prospective studies will unfold in detail the pathophysiological significance of UA in SSc patients with PH and determine its role as a prognostic marker in the assessment and monitoring of the disease.