Fracture probability assessed using FRAX in elderly women with benign paroxysmal positional vertigo
Fracture probability assessed using FRAX in elderly women with benign paroxysmal positional vertigo
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使用 FRAX 评估患有良性阵发性位置性眩晕的老年女性的骨折概率
DOI：
10.1016/j.anl.2018.05.002
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发表时间：
2018
影响因子：
1.7
通讯作者：
Sone Michihiko
中科院分区：
文献类型：
--
作者：
Nakada Takafumi;Teranishi Masaaki;Ueda Yukio;Sone Michihiko
目的良性阵发性位置性眩晕（BPPV）患者可能存在维生素D缺乏，这是导致骨转换异常的原因之一。一些研究已经确定了骨质疏松症和BPPV之间的关系。世界卫生组织骨折风险评估工具，广泛称为FRAX®（http：//www.shef.ac.uk/FRAX），是用于评估骨折风险的基于计算机的算法。BPPV患者和对照组的FRAX评分之间没有直接的比较。本研究的目的是确定是否与BPPV的妇女是在骨折的高风险评估使用FRAX.MethodsThe研究涉及40名绝经后妇女诊断BPPV 2015年7月和2016年4月之间，和40名绝经后妇女作为对照。使用FRAX计算10年主要股骨颈骨折和髋部骨折的风险，并使用Welch t检验和一般线性模型比较BPPV患者和对照组之间的风险。（年龄72.4 ± 8.6岁）和对照组（年龄71.2 ± 6.3岁）的14.3% ± 6.5%。BPPV患者的10年髋部骨折风险为9.0% ± 9.8%，对照组为5.0% ± 3.9%。与对照组相比，BPPV组的10年主要骨折风险（p= 0.0069）和髋部骨折风险（p= 0.0202）显著更高。同样，调整后的年龄，BPPV组有显着较高的10年的风险，主要骨质疏松性骨折（p= 0.0007）和髋部骨折（p= 0.0092）相比controls.ConclusionFracture的风险计算使用FRAX是显着高于BPPV组比对照组。患有BPPV的女性可能需要早期干预，以防止未来的骨折。
ObjectivePatients with benign paroxysmal positional vertigo (BPPV) can have vitamin D deficiency, which is a cause of abnormal bone turnover. Several studies have established a relationship between osteoporosis and BPPV. The World Health Organization Fracture Risk Assessment Tool, widely known as FRAX®(http://www.shef.ac.uk/FRAX), is a computer-based algorithm for assessing fracture risk. No direct comparison has been made between the FRAX scores of patients with BPPV and controls. The purpose of this study was to determine whether women with BPPV are at high risk of fracture as assessed using FRAX.MethodsThe study involved 40 postmenopausal women diagnosed with BPPV between July 2015 and April 2016, and 40 postmenopausal women as controls. The 10-year major osteoporotic and hip fracture risks were calculated using FRAX and were compared between BPPV patients and controls using Welch’s t test and a general linear model.ResultsThe 10-year major osteoporotic fracture risk was 20.4% ± 12.1% for BPPV patients (aged 72.4 ± 8.6 years) and 14.3% ± 6.5% for controls (aged 71.2 ± 6.3 years). The 10-year hip fracture risk was 9.0% ± 9.8% for BPPV patients and 5.0% ± 3.9% for controls. The BPPV group had significantly higher 10-year major risks of osteoporotic fracture (p= 0.0069) and hip fracture (p= 0.0202) compared with controls. Similarly, after adjustment for age, the BPPV group had significantly higher 10-year risks of major osteoporotic fracture (p= 0.0007) and hip fracture (p= 0.0092) compared with controls.ConclusionFracture risk calculated using FRAX was significantly higher in the BPPV group than in controls. Women with BPPV may need early intervention to prevent future fractures.