Medicinal foodstuffs. VII. On the saponin constituents with glucose and alcohol absorption-inhibitory activity from a food garnish "Tonburi", the fruit of Japanese Kochia scoparia (L.) Schrad.: structures of scoparianosides A, B, and C.
Medicinal foodstuffs. VII. On the saponin constituents with glucose and alcohol absorption-inhibitory activity from a food garnish "Tonburi", the fruit of Japanese Kochia scoparia (L.) Schrad.: structures of scoparianosides A, B, and C.
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DOI：
10.1248/cpb.45.1300
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发表时间：
1997-08
影响因子：
1.7
通讯作者：
M. Yoshikawa;H. Shimada;T. Morikawa;S. Yoshizumi;N. Matsumura;T. Murakami;H. Matsuda;K. Hori;J. Yamahara
中科院分区：
文献类型：
--
作者：
M. Yoshikawa;H. Shimada;T. Morikawa;S. Yoshizumi;N. Matsumura;T. Murakami;H. Matsuda;K. Hori;J. Yamahara
一种食品的甲醇提取物，用于装饰日本地肤果“tonburi”。施拉德。(藜科)，被发现能抑制血糖负荷大鼠的升高。通过生测分离，从该药用食品中分离得到苦瓜素IC及其2‘-O-β-D-吡喃葡萄糖苷和三个新的皂苷类化合物，分别命名为落新参皂苷A、B和C。根据化学和物理化学证据，确定其结构为：3β，22α-二羟基齐墩果酸(22α-羟基齐墩果酸)，3-O-β-D-木糖基(1->)；3)-β-D-吡喃葡萄糖醛酸、3-β-羟基-18-烯-28-吡喃酸(吗啉酸)、3-O-β-D-木糖苷(1->；3)-β-D-吡喃葡萄糖醛酸和3-β-羟基-13(18)-烯-28-酸、3-O-β-D-二甲氧基(1->；3)-β-D-吡喃葡萄糖醛酸。苦瓜素IC及其2‘-O-β-D-吡喃葡萄糖苷是该药用食品中的主要皂苷成分，可有效抑制大鼠对葡萄糖和乙醇的吸收。
The methanolic extract of a food garnish "Tonburi", the fruit of Japanese kochia scoparia (L.) Schrad. (Chenopodiaceae), was found to inhibit the increase in serum glucose-loaded rats. Through bioassay-guided separation, momordin Ic and its 2'-O-beta-D-glucopyranoside were isolated as the active principles from this medicinal foodstuff together with three new saponins named scoparianosides A, B, and C. The structures of scoparianosides A, B, and C were elucidated on the basis of chemical and physicochemical evidence as 3 beta, 22 alpha-dihydroxyolean-12en-28-oic acid (22 alpha-hydroxyoleanolic acid), 3-O-beta-D-xylopyranosyl (1 --> 3)-beta-D-glucopyranosiduronic acid, 3 beta-hydroxyolean -18-en-28-oic acid (morolic acid), 3-O-beta-D-xylopyranosyl(1 --> 3)-beta-D -glucopyranosiduronic acid, and 3 beta-hydroxyolean-13(18)-en-28-oic acid, 3-O-beta-D-xylopyranoxyl(1 --> 3) -beta-D-glucopyranosiduronic acid. Momordin Ic and its 2'-O-beta-D-glucopyranoside, both of which are the principal saponin constituents of this medicinal foodstuffs, were found to potently inhibit glucose and ethanol absorption in rats.