Sepsis and Acute Respiratory Distress Syndrome: Recent Update.
Sepsis and Acute Respiratory Distress Syndrome: Recent Update.
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DOI：
10.4046/trd.2016.79.2.53
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发表时间：
2016-04
影响因子：
2.9
通讯作者：
Hong SB
中科院分区：
文献类型：
--
作者：
Kim WY;Hong SB
严重脓毒症或脓毒性休克的特征是对感染性病原体的过度炎症反应。急性呼吸窘迫综合征（acute respiratory distress syndrome，ARDS）是严重脓毒症的严重并发症，病死率高。近几十年来，肺保护性通气、俯卧位、神经肌肉阻滞和体外膜肺氧合等治疗方式的进步改善了预后，但死亡率仍然很高。及时治疗潜在的脓毒症和早期识别有ARDS风险的患者有助于减少其发展。此外，还需要进一步研究其发病机制和新的治疗方法，以显示脓毒症诱导的ARDS的有前途的未来治疗。
Severe sepsis or septic shock is characterized by an excessive inflammatory response to infectious pathogens. Acute respiratory distress syndrome (ARDS) is a devastating complication of severe sepsis, from which patients have high mortality. Advances in treatment modalities including lung protective ventilation, prone positioning, use of neuromuscular blockade, and extracorporeal membrane oxygenation, have improved the outcome over recent decades, nevertheless, the mortality rate still remains high. Timely treatment of underlying sepsis and early identification of patients at risk of ARDS can help to decrease its development. In addition, further studies are needed regarding pathogenesis and novel therapies in order to show promising future treatments of sepsis-induced ARDS.