Microbe Profile: Salinispora tropica: natural products and the evolution of a unique marine bacterium.
Microbe Profile: Salinispora tropica: natural products and the evolution of a unique marine bacterium.
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微生物概况：热带盐孢菌：天然产物和独特海洋细菌的进化。
DOI：
10.1099/mic.0.001163
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Jensen,PaulR
中科院分区：
文献类型：
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作者：
Jensen,PaulR
热带盐孢放线菌（Salinispora tropica）最初是从热带海洋沉积物中培养出来的，是第一个专性海洋放线菌属。在发现后不久，它产生了有效的蛋白酶体抑制剂salinosporamide A，这是一种结构新颖的天然产物，目前正在进行治疗癌症的III期临床试验。如果获得批准，它将是第一个从培养的海洋微生物中获得的具有临床意义的天然产品。热带雨林生产许多其他具有生物活性的天然产品，包括一些与化学防御有关的产品，从而为其生产提供了生态环境。然而，基因组分析显示，大多数天然产物生物合成基因簇仍然是孤儿，这表明更多的化合物等待发现。热带雨林中丰富的生物合成基因簇支持了这样一个概念，即它们编码的小分子具有重要的生态功能，而它们的进化历史表明它们在促进多样化方面具有潜在的作用。更好地了解微生物天然产物的生态功能将有助于为未来的发现工作提供信息。
Salinispora tropicawas originally cultured from tropical marine sediments and described as the first obligate marine actinomycete genus. Soon after its discovery, it yielded the potent proteasome inhibitor salinosporamide A, a structurally novel natural product that is currently in phase III clinical trials for the treatment of cancer. If approved, it will be the first natural product derived from a cultured marine microbe to achieve clinical relevance.S. tropicaproduces many other biologically active natural products, including some linked to chemical defence, thus providing ecological context for their production. However, genomic analyses reveal that most natural product biosynthetic gene clusters remain orphan, suggesting that more compounds await discovery. The abundance of biosynthetic gene clusters inS. tropicasupports the concept that the small molecules they encode serve important ecological functions, while their evolutionary histories suggest a potential role in promoting diversification. Better insights into the ecological functions of microbial natural products will help inform future discovery efforts.