Childhood‐onset schizophrenia and tryptophan hydroxylase gene polymorphism
Childhood‐onset schizophrenia and tryptophan hydroxylase gene polymorphism
复制标题
DOI：
10.1002/ajmg.b.30009
复制
发表时间：
2004-07
期刊：
影响因子：
--
通讯作者：
Takahiro Sekizawa;Y. Iwata;Kazuhiko Nakamura;H. Matsumoto;A. Suzuki;Katsuaki Suzuki;Y. Sekine;N. Takei;Y. Minabe;N. Mori
中科院分区：
文献类型：
--
作者：
Takahiro Sekizawa;Y. Iwata;Kazuhiko Nakamura;H. Matsumoto;A. Suzuki;Katsuaki Suzuki;Y. Sekine;N. Takei;Y. Minabe;N. Mori
在一个日本样本中，我们探讨了色氨酸羟基酶基因多态性与儿童期精神分裂症易感性的关系。受试者是51名16岁前符合DSM-IV精神分裂症标准的日本患者和148名日本健康对照组。儿童精神分裂症组A等位基因频率明显高于对照组(优势比OR=1.47，95%CI=0.97~2.37，P=0.097)。与其他基因型组相比，AA型儿童精神分裂症发病风险增加近一倍；OR=1.97，95%CI=0.91-4.22，P=0.058。©2004 Wiley-Liss Inc.
We explored the relationship between the tryptophan hydroxylase gene polymorphism and susceptibility to childhood‐onset schizophrenia in a Japanese sample. Subjects were 51 Japanese patients who met DSM‐IV criteria for schizophrenia before age 16 and 148 Japanese healthy controls. DNA was extracted from whole blood and genotyping was performed by PCR‐RFLP using Nhe I. The frequency of the A allele was relatively higher in patients with childhood‐onset schizophrenia than in controls (odds ratio, OR = 1.47, 95% CI = 0.97–2.37, P = 0.097). There was a nearly doubling of the risk for childhood‐onset schizophrenia associated with the AA genotype compared to other genotype groups; OR = 1.97, 95% CI = 0.91–4.22, P = 0.058. © 2004 Wiley‐Liss, Inc.