Cell-size dependent progression of the cell cycle creates homeostasis and flexibility of plant cell size.
Cell-size dependent progression of the cell cycle creates homeostasis and flexibility of plant cell size.
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DOI：
10.1038/ncomms15060
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发表时间：
2017-04-27
影响因子：
16.6
通讯作者：
Murray JAH
中科院分区：
文献类型：
--
作者：
R Jones A;Forero-Vargas M;Withers SP;Smith RS;Traas J;Dewitte W;Murray JAH
Mean cell size at division is generally constant for specific conditions and cell types, but the mechanisms coupling cell growth and cell cycle control with cell size regulation are poorly understood in intact tissues. Here we show that the continuously dividing fields of cells within the shoot apical meristem of Arabidopsis show dynamic regulation of mean cell size dependent on developmental stage, genotype and environmental signals. We show cell size at division and cell cycle length is effectively predicted using a two-stage cell cycle model linking cell growth and two sequential cyclin dependent kinase (CDK) activities, and experimental results concur in showing that progression through both G1/S and G2/M is size dependent. This work shows that cell-autonomous co-ordination of cell growth and cell division previously observed in unicellular organisms also exists in intact plant tissues, and that cell size may be an emergent rather than directly determined property of cells. The mechanistic coupling of cell growth and cell cycle control with cell size regulation in tissues is not well understood. Here, the authors show that within the shoot apical meristem of Arabidopsis cell size depends on developmental stage, genotype and environmental signals; however cell growth and cell division are cell-autonomously coordinated.
