EVIDENCE THAT NITRIC-OXIDE MODULATES FOOD-INTAKE IN MICE
EVIDENCE THAT NITRIC-OXIDE MODULATES FOOD-INTAKE IN MICE
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DOI：
10.1016/0024-3205(91)90102-h
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发表时间：
1991-01-01
期刊：
影响因子：
6.1
通讯作者：
FLOOD, JF
中科院分区：
文献类型：
--
作者：
MORLEY, JE;FLOOD, JF
一氧化氮（NO）可能是中枢神经系统内的细胞间调节剂。L-精氨酸可促进NO合成，增加小鼠摄食量，而NO合成抑制剂L-N（G）-硝基精氨酸（L-NO Arg）可抑制饥饿小鼠的摄食量。L-精氨酸可部分逆转L-NO Arg对摄食的抑制作用，而D-精氨酸则不能。这些研究结果表明，NO可能是一种生理调节剂的食物摄入量和探索的可能性L-NO精氨酸在治疗肥胖症的效用应进行探讨。
Nitric oxide (NO) may be an intercellular modulator within the central nervous system. L-arginine, which results in No synthesis, increased food intake in mice while the inhibitor of NO synthesis, L-N(G)-nitro arginine (L-NO Arg) inhibited food intake in food deprived mice. L-arginine, but not D-arginine, partially reversed the inhibitory effect of L-NO Arg on food intake. These findings suggest the possibility that NO may be a physiological modulator of food intake and that the possibility of exploring the utility of L-NO arg in the treatment of obesity should be explored.