Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases
Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases
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DOI：
10.1097/00062752-200201000-00003
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发表时间：
2002-01-01
影响因子：
3.2
通讯作者：
Lambeth, JD
中科院分区：
文献类型：
--
作者：
Lambeth, JD
活性氧类被经典地描述为呼吸作用的意外副产品，通常被认为对生物系统有害。吞噬细胞烟酰胺腺嘌呤二核苷酸磷酸氧化酶提供了一个故意产生活性氧物种的例子，但这种酶的功能是氧化修饰细菌，作为杀菌机制的一部分。与吞噬细胞氧化酶相关的烟酰胺腺嘌呤二核苷酸(磷酸)氧化酶家族--NOx/DUOX家族的发现，提供了故意产生活性氧物种的另一个例子。本文描述了这一新的酶家族，并考虑了对其功能的假设。讨论了NOx/DUOX在细胞信号转导(与生长和血管生成相关)、免疫功能、低氧反应和细胞外基质蛋白氧化修饰中的潜在作用。(C)2002年Lippincott Williams&Wilkins，Inc.
Reactive oxygen species are classically described as occurring as an accidental byproduct of respiration, and are generally thought to be deleterious to biologic systems. The phagocyte nicotinamide adenine dinucleotide phosphate oxidase provides an example of deliberate reactive oxygen species generation, but the function of this enzyme is to oxidatively modify bacteria as part of bactericidal mechanisms. The discovery of a family of nicotinamide adenine dinucleotide (phosphate) oxidases related to the phagocyte oxidase, the Nox/Duox family, provides additional examples of deliberate generation of reactive oxygen species. This article describes this new family of enzymes and considers hypotheses for their function. Potential roles of Nox/Duox in generation of reactive oxygen species that function in cell signaling (related to growth and angiogenesis), immune function, hypoxic response, and oxidative modification of extracellular matrix proteins are discussed. (C) 2002 Lippincott Williams & Wilkins, Inc.