MDA: a psychoactive agent with dual stimulus effects.
MDA: a psychoactive agent with dual stimulus effects.
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MDA：具有双重刺激作用的精神活性剂。
DOI：
10.1016/0024-3205(84)90627-1
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发表时间：
1984
期刊：
影响因子：
6.1
通讯作者：
Young,R
中科院分区：
文献类型：
--
作者：
Glennon,RA;Young,R
大鼠被训练从生理盐水中区分(+)-安非他明（1.0 mg/kg）或外消旋丙二醛（1.5 mg/kg）注射。在各组的识别表现稳定（约85%）后，进行刺激泛化研究。安非他明的刺激作用扩展到丙二醛，但不扩展到致幻剂DOM；mda刺激对苯丙胺和DOM均有影响。结合我们之前的发现，dom刺激泛化发生在MDA而非安非他明身上，本研究表明MDA能够在动物中产生双重刺激作用。除了这些显著特征外，本研究的结果也对刺激特异性产生了影响，并进一步强调了在刺激泛化测试中全面的剂量-反应关系的重要性。
Rats were trained to discriminate injections of either (+)-amphetamine (1.0 mg/kg) or racemic MDA (1.5 mg/kg) from saline in a two-lever drug discrimination task. After stable discrimination performances (>85%) were attained in each group, stimulus generalization studies were conducted. The amphetamine-stimulus generalized to MDA, but not to the hallucinogenic agent DOM; the MDA-stimulus generalized to both amphetamine and DOM. Taken together with our previous finding that DOM-stimulus generalization occurs to MDA but not to amphetamine, the present study suggests that MDA is capable of producing dual stimulus effects in animals. In addition to these salient features, the results of this study also have an impact on stimulus specificity, and further emphasize the importance of thorough dose-response relationships as related to tests of stimulus generalization.