In situ structural and microangiographic assessment of human skin lesions with high-speed OCT.
In situ structural and microangiographic assessment of human skin lesions with high-speed OCT.
复制标题
使用高速 OCT 对人体皮肤病变进行原位结构和微血管造影评估。
DOI：
10.1364/boe.3.002636
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发表时间：
2012-10-01
影响因子：
3.4
通讯作者：
Leitgeb RA
中科院分区：
文献类型：
--
作者：
Blatter C;Weingast J;Alex A;Grajciar B;Wieser W;Drexler W;Huber R;Leitgeb RA
我们证明了非侵入性的结构和微血管对比成像不同的人类皮肤疾病在体内使用的OCT断层图像的强度差异分析。高速扫频光源OCT系统工作波长为1310 nm，A扫描速率为220 kHz。它通过采用贝塞尔光束提供扩展的焦点。研究的病变是两例皮炎和两例基底细胞癌。病变显示出与健康皮肤显著不同的特征性血管模式。在炎症的情况下，血管扩张，灌注增加。在基底细胞癌的情况下，血管造影显示无组织的血管网络更密集，大血管靠近皮肤表面。这些结果表明，评估血管变化产生补充信息，对代谢需求具有重要的洞察力。
We demonstrate noninvasive structural and microvascular contrast imaging of different human skin diseases in vivo using an intensity difference analysis of OCT tomograms. The high-speed swept source OCT system operates at 1310 nm with 220 kHz A-scan rate. It provides an extended focus by employing a Bessel beam. The studied lesions were two cases of dermatitis and two cases of basal cell carcinoma. The lesions show characteristic vascular patterns that are significantly different from healthy skin. In case of inflammation, vessels are dilated and perfusion is increased. In case of basal cell carcinoma, the angiogram shows a denser network of unorganized vessels with large vessels close to the skin surface. Those results indicate that assessing vascular changes yields complementary information with important insight into the metabolic demand.