Mitochondrial Biogenesis through Activation of Nuclear Signaling Proteins
Mitochondrial Biogenesis through Activation of Nuclear Signaling Proteins
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DOI：
10.1101/cshperspect.a015008
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发表时间：
2013-07-01
影响因子：
7.2
通讯作者：
Puigserver, Pere
中科院分区：
文献类型：
--
作者：
Dominy, John E.;Puigserver, Pere
线粒体生物发生和功能的动力学是细胞和分子过程的复杂相互作用，最终塑造生物能能力。线粒体质量本身代表生物发生率和降解率之间的净平衡。线粒体生物发生依赖于促进线粒体形成和组装的不同信号级联和转录复合物，这一过程在很大程度上依赖于对线粒体蛋白编码基因的及时和协调的转录控制。在本文中，我们讨论主要信号和转录复合物、编程线粒体生物发生和生物能量活动。该调节网络代表了治疗以线粒体动力学失调和生物能缺陷为特征的广泛线粒体和神经退行性疾病的新治疗窗口。
The dynamics of mitochondrial biogenesis and function is a complex interplay of cellular and molecular processes that ultimately shape bioenergetics capacity. Mitochondrial mass, by itself, represents the net balance between rates of biogenesis and degradation. Mitochondrial biogenesis is dependent on different signaling cascades and transcriptional complexes that promote the formation and assembly of mitochondria-a process that is heavily dependent on timely and coordinated transcriptional control of genes encoding for mitochondrial proteins. In this article, we discuss the major signals and transcriptional complexes, programming mitochondrial biogenesis, and bioenergetic activity. This regulatory network represents a new therapeutic window into the treatment of the wide spectrum of mitochondrial and neurodegenerative diseases characterized by dysregulation of mitochondrial dynamics and bioenergetic deficiencies.