ABSORPTION OF PROTEIN FROM THE PERITONEAL CAVITY
ABSORPTION OF PROTEIN FROM THE PERITONEAL CAVITY
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DOI：
10.1113/jphysiol.1951.sp004626
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发表时间：
1951-01-01
影响因子：
5.5
通讯作者：
STEINBECK, AW
中科院分区：
文献类型：
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作者：
COURTICE, FC;STEINBECK, AW
注射了几组大鼠。intraperit。用0.9% NaCl，将大鼠、牛、人、兔和豚鼠的血浆和晶体牛白蛋白进行肝素化处理。在大多数实验中，该蛋白被标记为T-1824。液体剂量为20 ml /kg。大鼠血浆吸收速度略快于0.9% NaCl。新鲜的异种血浆在最初的3-8小时内产生初始反应，引起腹腔内液体体积的增加。然后吸收率增加，并可能在16小时后完全吸收。溶液。结晶牛白蛋白或储存的异种血浆在没有任何初始反应的情况下被迅速吸收。改变这些液体进入腹腔的位置蛋白质趋向于达到一种平衡，大概是与腹膜组织液中的蛋白质。兔或牛血浆在吸收过程中出现胸膜积液，而大鼠血浆没有。这被认为是由于淋巴的逃逸。
Groups of rats were injd. intraperit. with 0.9% NaCl, rat, bovine, human, rabbit and guinea-pig heparinized plasma and soln. of crystalline bovine albumin. The protein was tagged with T-1824 in most expts. The dose of fluid was 20 ml./kg. The rat plasma is slightly more rapidly absorbed than is 0.9% NaCl. Fresh heterologous plasmas produce an initial reaction causing an increase in the volume of fluid placed in the peritoneal cavity for the 1st 3-8 hrs. and then the rate of absorption increases and may be completely absorbed at the end of 16 hrs. Solns. of crystalline bovine albumin or stored heterologous plasmas are rapidly absorbed without any initial reaction. Alter placement of these fluids into the peritoneal cavity, the concn. of protein tended to reach an equilibrium, presumably with the protein in the tissue fluid of the peritoneum. With rabbit or bovine plasma but not with rat plasma, pleural fluid appeared during absorption. This was considered as due to escape from lymphatics.