The Effect of Comorbidity on the Prognosis of Acute Lung Injury and Acute Respiratory Distress Syndrome
The Effect of Comorbidity on the Prognosis of Acute Lung Injury and Acute Respiratory Distress Syndrome
复制标题
DOI：
10.2169/internalmedicine.51.6434
复制
发表时间：
2012-01-01
影响因子：
1.2
通讯作者：
Kaneko, Norihiro
中科院分区：
文献类型：
--
作者：
Ando, Katsutoshi;Doi, Tokuhide;Kaneko, Norihiro
目的回顾性分析2004年4月至2009年7月收治的47例急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）患者的临床资料，采用Charlson并发症指数（CCI）评估并发症与ALI和ARDS的关系。在确诊后3个月将患者分为生存组和非生存组，分析人口统计学和临床特征。我们还评估了ROC曲线和Akaike信息标准（AIC），以确定3个月生存期时CCI的最合适截止值。根据AIC结果估计生存率。结果平均年龄为71.0岁; 25例（53%）患者在诊断后3个月内死亡。尽管两组患者的年龄、ALI和ARDS的病因以及APACHE II评分没有差异，但非存活组的吸烟史、CCI、SOFA评分和类固醇使用率高于存活组。年龄与CCI无显著相关性;然而，CCI与APACHE II和SOFA评分有微弱但有统计学意义的相关性（r=0.387，p
Objective We conducted a retrospective study assessing the relationship between comorbidity, using the Charlson Comorbidity Index (CCI), and the prognoses of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) patients.Methods We analyzed the data of 47 patients with ALI and ARDS who were admitted to our center between April 2004 and July 2009. The patients were classified into 2 groups (survival and non-survival) 3 months after diagnosis, and demographic and clinical characteristics were analyzed. We also evaluated the ROC curve and Akaike's information criterion (AIC) to determine the most appropriate cut-off level for the CCI at 3 months survival. The survival rate was estimated based on the AIC results.Results The mean age was 71.0 years; 25 (53%) of the patients died within 3 months of the diagnosis. Although age, etiology of ALI and ARDS, and APACHE II score did not differ between the two groups, smoking history, CCI, SOFA score, and steroid use were higher in the non-survival group than in the survival group. Age was not significantly correlated with CCI; however, CCI had weak, but statistically significant correlations with the APACHE II and SOFA scores (r=0.387, p