Biologic markers of invasive pituitary adenomas involving the sphenoid sinus.
Biologic markers of invasive pituitary adenomas involving the sphenoid sinus.
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涉及蝶窦的侵袭性垂体腺瘤的生物标志物。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
L. Barnes
中科院分区：
文献类型：
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作者：
Regina F Gandour;S. Kapadia;I. Janecka;A. Martínez;L. Barnes
侵袭性垂体腺瘤的生物学行为尚不清楚，似乎介于鞍内腺瘤和垂体癌之间。我们利用免疫组化技术对10例侵犯蝶窦的侵袭性垂体腺瘤进行细胞和分子标记，并与10例非侵袭性垂体腺瘤和5例正常垂体腺进行比较。面板包括Ki-67和PCNA（增殖细胞核抗原），细胞增殖指标；白细胞介素6 (IL-6)，一种多功能细胞因子；热休克蛋白27 (HSP 27)，应激反应蛋白；还有p53，一种肿瘤抑制基因产物。我们发现IL-6在正常垂体、20%的非侵袭性腺瘤和50%的侵袭性腺瘤中表达强烈。HSP 27在正常腺体中不存在，而在10%的非侵袭性腺瘤和50%的侵袭性腺瘤中存在。Ki-67和PCNA增殖指数高于正常，但两组基本相同。在所有标本中未检测到P53。我们认为IL-6和HSP 27可能是垂体腺瘤生物侵袭的标志物。
The biologic behavior of invasive pituitary adenomas is poorly understood and appears to be intermediate between intrasellar adenomas and pituitary carcinoma. Utilizing immunohistochemistry on tissue sections, we examined 10 invasive pituitary adenomas involving the sphenoid sinus with a panel of cellular and molecular markers and compared the results with 10 noninvasive pituitary adenomas and five normal pituitary glands. The panel included Ki-67 and PCNA (proliferation cell nuclear antigen), cell proliferation indicators; interleukin 6 (IL-6), a multifunctional cytokine; heat shock protein 27 (HSP 27), a stress response protein; and p53, a tumor suppressor gene product. We found strong expression of IL-6 in normal pituitary glands, 20% of noninvasive and 50% of invasive adenomas. HSP 27 was absent in normal glands and present in 10% of noninvasive and 50% of invasive adenomas. The Ki-67 and PCNA proliferation index was above normal but was essentially the same in the two groups. p53 was not detected in any specimens. We propose that both IL-6 and HSP 27 may be markers of biologic aggression in pituitary adenomas.