PREPARATION OF POLY(GLYCOLIC ACID) BONDED FIBER STRUCTURES FOR CELL ATTACHMENT AND TRANSPLANTATION
PREPARATION OF POLY(GLYCOLIC ACID) BONDED FIBER STRUCTURES FOR CELL ATTACHMENT AND TRANSPLANTATION
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DOI：
10.1002/jbm.820270207
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发表时间：
1993-02-01
期刊：
影响因子：
--
通讯作者：
LANGER, R
中科院分区：
文献类型：
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作者：
MIKOS, AG;BAO, Y;LANGER, R
发展了一种新的方法来制备具有所需形状的三维结构作为细胞移植的模板。所生产的生物材料是高度多孔的，具有大的表面/体积，并为移植细胞的附着和增殖提供必要的空间。该加工技术要求形成一种复合材料，该复合材料具有嵌入基质中的非粘合纤维，然后进行热处理和选择性溶解基质。为了评价该技术，使用聚（L-乳酸）（PLLA）作为基质粘合聚（乙醇酸）（PGA）纤维补片。粘结的结构是高度多孔的孔隙率高达0.81和面积/体积比高达0.05妈妈-1的值。
A novel method was developed to prepare three-dimensional structures with desired shapes used as templates for cell transplantation. The produced bio-materials are highly porous with large surface/volume and provide the necessary space for attachment and proliferation of the transplanted cells. The processing technique calls for the formation of a composite material with nonbonded fibers embedded in a matrix followed by thermal treatment and the selective dissolution of the matrix. To evaluate the technique, poly(glycolic acid) (PGA) fiber meshes were bonded using poly(L-lactic acid) (PLLA) as a matrix. The bonded structures were highly porous with values of porosity up to 0.81 and area/volume ratios as high as 0.05 mum-1.