Ranking the Influence of Tissue Conductivities on Forward-Calculated ECGs
Ranking the Influence of Tissue Conductivities on Forward-Calculated ECGs
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DOI：
10.1109/tbme.2010.2046485
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发表时间：
2010-07-01
影响因子：
4.6
通讯作者：
Doessel, Olaf
中科院分区：
文献类型：
--
作者：
Keller, David U. J.;Weber, Frank M.;Doessel, Olaf
本文研究了不同组织电导率对正演计算心电图的影响。为此，我们通过在改变各自组织电导率的同时进行重复的正演计算来对组织的影响进行排名。躯干模型包括所有主要解剖结构，如血液、肺、脂肪、各向异性骨骼肌、肠、肝、肾、骨、软骨和脾。心脏电源来源于真实的心房和心室模拟。电导率排名基于以下两种方法之一：首先，我们考虑固定百分比电导率变化来探测ECG对电导率变化的敏感性。其次，我们将电导率设置为报告的最小值和最大值，以评估现有电导率不确定性的影响。心房和心室心电图的振幅对血液、骨骼肌电导率和各向异性以及心脏、脂肪和肺部最敏感。如果考虑信号形态，脂肪更重要，而骨骼肌则不那么重要。当比较心房和心室时，肺对心房的影响更大，而心脏电导率对心室的影响更大。电导率不确定度的影响是显著的。未来的心电图模拟研究应该考虑这些影响。
This paper examined the effects that different tissue conductivities had on forward-calculated ECGs. To this end, we ranked the influence of tissues by performing repetitive forward calculations while varying the respective tissue conductivity. The torso model included all major anatomical structures like blood, lungs, fat, anisotropic skeletal muscle, intestine, liver, kidneys, bone, cartilage, and spleen. Cardiac electrical sources were derived from realistic atrial and ventricular simulations. The conductivity rankings were based on one of two methods: First, we considered fixed percental conductivity changes to probe the sensitivity of the ECG regarding conductivity alterations. Second, we set conductivities to the reported minimum and maximum values to evaluate the effects of the existing conductivity uncertainties. The amplitudes of both atrial and ventricular ECGs were most sensitive for blood, skeletal muscle conductivity and anisotropy as well as for heart, fat, and lungs. If signal morphology was considered, fat was more important whereas skeletal muscle was less important. When comparing atria and ventricles, the lungs had a larger effect on the atria yet the heart conductivity had a stronger impact on the ventricles. The effects of conductivity uncertainties were significant. Future studies dealing with electrocardiographic simulations should consider these effects.