Recurrence of focal segmental glomerulosclerosis posttransplantation: a special report of the North American Pediatric Renal Transplant Cooperative Study.
Recurrence of focal segmental glomerulosclerosis posttransplantation: a special report of the North American Pediatric Renal Transplant Cooperative Study.
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移植后局灶节段性肾小球硬化的复发：北美儿童肾移植合作研究的特别报告。
DOI：
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发表时间：
1992
影响因子：
13.6
通讯作者：
D. Stablein
中科院分区：
文献类型：
--
作者：
A. Tejani;D. Stablein
在各种形式的肾小球肾炎中，局灶节段性肾小球硬化症（FSGS）是导致儿童移植的终末期肾病的最常见原因。之前关于 FSGS 复发的报道差异很大。北美儿童肾移植合作研究进行了一项专门研究，以确定 132 例移植手术的复发率和导致复发的危险因素。百分之五十五的患者是白人儿童，其余的是黑人和西班牙裔儿童。 50% 的患者在诊断 FSGS 时年龄在 5 岁以下。 132 名患者中有 27 名 (20.5%)（95% 置信区间，14 至 27）经活检证实 FSGS 复发。中位复发时间为 14 天。与西班牙裔儿童 (20%) 相比，白人儿童 (23%) 的复发率相似，但低于黑人儿童 (9%)（32 名儿童中的 3 名）。2+ (20%)。复发患者的平均血清白蛋白水平为 1.7 g/dL，而未复发患者的平均血清白蛋白水平为 2.0 g/dL。复发患者的平均血清胆固醇水平为 525 mg/dL，而未复发患者的平均血清胆固醇水平为 476 mg/dL。两组的透析持续时间相似。复发患者从诊断到终末期肾病状态的平均时间为 33 个月，未复发患者为 52 个月（P 小于 0.05）。（摘要截短 250 字）
Among various forms of glomerulonephritis, focal segmental glomerulosclerosis (FSGS) is the most common cause of end-stage renal disease leading to transplantation in children. Previous reports of the recurrence of FSGS vary widely. The North American Pediatric Renal Transplant Cooperative Study carried out a special study to determine the rate of recurrence and risk factors leading to recurrence in 132 transplants. Fifty-five percent of the patients were white children, and the remaining were black and Hispanic children. Fifty percent of the patients were under 5 yr of age at the time of the diagnosis of FSGS. Twenty-seven (20.5%) of 132 patients (95% confidence interval, 14 to 27) had a biopsy-proven recurrence of FSGS. The median time to recurrence was 14 days. The recurrence rate was similar in white children (23%) when compared with that in Hispanic children (20%) but was lower than that in black children (9%) (3 of 32 children).2+ (20%). The mean serum albumin level of patients with recurrence was 1.7 versus 2.0 g/dL for those without recurrence. The mean serum cholesterol level of patients with recurrence was 525 versus 476 mg/dL for those without recurrence. The duration of dialysis was similar in the two groups. The mean time from diagnosis to end-stage renal disease status was 33 months for patients with recurrence and 52 months for those without recurrence (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
肾移植后儿童局灶节段性硬化症的复发。
DOI：
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发表时间：
1986
期刊：
Kidney international. Supplement
影响因子：
--
作者：
Striegel,JE;Sibley,RK;Fryd,DS;Mauer,SM
通讯作者：
Mauer,SM