Social factors and individual vulnerability to chronic stress exposure
Social factors and individual vulnerability to chronic stress exposure
复制标题
DOI：
10.1016/j.neubiorev.2004.06.009
复制
发表时间：
2005-02-01
影响因子：
8.2
通讯作者：
Parmigiani, S
中科院分区：
文献类型：
--
作者：
Bartolomucci, A;Palanza, P;Parmigiani, S
压力反应在短期内是适应性的，但如果长期维持其介质的持续水平，它可能是不适应的。此外，并非所有暴露于慢性压力下的个体都会发展成疾病。因此，了解个体差异的原因和脆弱性变化的后果是非常重要的。这篇综述的目的是通过提出一种新的自然的雄性小鼠慢性社会心理应激模型来阐明这一问题。入住/闯入对小鼠生活在持续的感官接触和每天的身体互动中。研究确定了四种类型：常住优势型、常住从属型、入侵者优势型和入侵者从属型。研究了应激小鼠的行为、自主神经和免疫功能、下丘脑-垂体-肾上腺皮质反应、脑细胞因子表达和心脏组织学。在所有小鼠中都存在与社会地位无关的某些应激诱导的改变，而其他小鼠则明显区分了优势与从属。RS小鼠显示出一种独特的改变，表明相关资源（如领土）的丧失是决定为什么只有某些暴露于压力下的个体最终表现出恶性肿瘤和精神病理的关键因素。(C) 2004 Elsevier Ltd.版权所有。
The stress-response is adaptive in the short-term, but it can be maladaptive if sustained levels of its mediators are chronically maintained. Furthermore, not all individuals exposed to chronic stress will progress to disease. Thus, understanding the causes of individual differences and the consequences of variation in vulnerability is of major importance. The aim of this review is to shed light on this issue by presenting a new naturalistic model of chronic psychosocial stress in male mice. Resident/intruder pairs of mice lived in continuous sensory contact and physically interacted daily. Four categories were identified: Resident Dominant, Resident Subordinate (RS), Intruder Dominant, and Intruder Subordinate. Behavior, autonomic and immune functions, hypothalamic-pituitary-adrenocortical responses, brain cytokine expression and cardiac histology were investigated in stress-exposed mice. Certain stress-induced alterations were present in all mice independent of their social status, while others clearly differentiated dominants from subordinates. RS mice showed a unique profile of alterations suggesting that the loss of relevant resources, such as the territory, is the key factor determining why only certain stress-exposed individuals ultimately show malignancy and psychopathologies. (C) 2004 Elsevier Ltd. All rights reserved.