Metapneumovirus and acute wheezing in children.
Metapneumovirus and acute wheezing in children.
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DOI：
10.1016/s0140-6736(02)11391-2
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发表时间：
2002-11-02
期刊：
影响因子：
--
通讯作者：
Ruuskanen O
中科院分区：
文献类型：
--
作者：
Jartti T;van den Hoogen B;Garofalo RP;Osterhaus AD;Ruuskanen O
最近发现了一种新的呼吸道病毒--人偏肺病毒。我们在芬兰图尔库医院因急性呼气性喘息(平均年龄7个月，4-25岁)住院的132名连续儿童中的10名(8%)用聚合酶链式反应检测到这种病毒。平均住院时间2.5d(SD1.6)，平均呼吸道症状持续时间19d(8例)。鼻腔分泌物中白细胞计数、C反应蛋白、活化调节、正常T细胞表达和T细胞分泌(RANTES)浓度维持在较低水平，而鼻液中白细胞介素8浓度较高。人类偏肺病毒是引起幼儿急性喘息的重要临床病原体。
A new respiratory virus, human metapneumovirus, was recently identified. We detected this virus by PCR in ten (8%) of 132 consecutive children admitted to Turku Hospital, Finland, for acute expiratory wheezing (median age 7 months, range 4–25). The mean duration of hospital stay was 2·5 days (SD 1·6) and mean duration of respiratory symptoms was 19 days (8). The white blood cell count, C-reactive protein, and regulated upon activation, normal T-cell-expressed and T-cell-secreted (RANTES) concentrations in nasal secretion remained low, whereas interleukin 8 concentrations in nasal secretion were high. Human metapneumovirus is a clinically important causative agent of acute wheezing in young children.