A new X-ray computed tomography system for laboratory mouse imaging
A new X-ray computed tomography system for laboratory mouse imaging
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DOI：
10.1109/23.775579
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发表时间：
1999-06-01
影响因子：
1.8
通讯作者：
Allen, WC
中科院分区：
文献类型：
--
作者：
Paulus, MJ;Sari-Sarraf, H;Allen, WC
橡树岭国家实验室哺乳动物遗传学研究机构正在开发两种新的高分辨率x射线计算机断层扫描系统，用于筛选诱变小鼠。第一个原型采用单像素碲化镉锌探测器，其针孔准直器在脉冲计数模式下工作。第二个版本采用在电流模式下工作的荧光粉屏/CCD检测器。主要系统硬件包括一个低能x射线管，两个线性平移台和一个旋转台。对于单像素探测器，图像分辨率由探测器级的步长决定；在100毫米和250毫米分辨率下获得了初步图像。荧光屏探测器的分辨率由荧光屏的调制传递函数决定；已获得分辨率接近50 μ m的图像。介绍了这两种探测器的系统性能，并给出了最新的图像。
Two versions of a new high-resolution x-ray computed tomography system are being developed to screen mutagenized mice in the Oak Ridge National Laboratory Mammalian Genetics Research Facility. The first prototype employs a single-pixel cadmium zinc telluride detector with a pinhole collimator operating in pulse counting mode. The second version employs a phosphor screen/CCD detector operating in current mode. The major system hardware includes a low-energy x-ray tube, two linear translation stages and a rotational stage. For the single-pixel detector, image resolution is determined by the step size of the detector stage; preliminary images have been acquired at 100 Irm and 250 mu m resolutions. The resolution of the phosphor screen detector Is determined by the modulation transfer function of the phosphor screen; images with resolutions approaching 50 mu m have been acquired. The system performance with the two detectors is described and recent images are presented.