THE ROLE OF IGG GLYCOFORMS IN THE PATHOGENESIS OF RHEUMATOID-ARTHRITIS
THE ROLE OF IGG GLYCOFORMS IN THE PATHOGENESIS OF RHEUMATOID-ARTHRITIS
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DOI：
10.1007/bf01857227
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发表时间：
1988-01-01
期刊：
影响因子：
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通讯作者：
ROITT, I
中科院分区：
文献类型：
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作者：
RADEMACHER, TW;PAREKH, RB;ROITT, I
结论总之，在活动性类风湿性关节炎（青少年和成人）、结核病和克罗恩病中，IgG糖型人群向无半乳糖基双触角N-连接寡糖含量较高的人群转变，但在其他各种风湿性、炎症或感染性疾病中则不然。这种转变可能有助于疾病的发病机制，通过免疫复合物的形成，并通过针对非还原性末端G1 cNAc表位的细胞网络的干扰。在每种情况下，精确的病理学将由产生这种IgG的解剖学位点以及诱导IgG糖基化的这种变化的精确机制来调节。这些机制中重要的可能是环境和内源性碳水化合物表位之间的交叉反应性。这将是有趣的，看看未来的研究是否支持这一想法，即疾病组（e。例如，在一个实施例中，类风湿性关节炎、肺结核、克罗恩病）确实通过共同的病因学相关[i.例如，G（0）]。
ConclusionsIn conclusion, there is a shift in the population of IgG glycoforms towards those with a higher content of agalactosyl biantennary N-linked oligosaccharides in active rheumatoid arthritis (both juvenile and adult), tuberculosis, and Crohn's disease, but not in a variety of other rheumatological, inflammatory, or infectious conditions. This shift may contribute to disease pathogenesis both through immune-complex formation and through disturbance of a cellular network directed against the non-reducing terminal G1cNAc epitope. The precise pathology would in each case be modulated by the anatomical site(s) of production of such IgG, and also by the precise mechanism inducing this change in IgG glycosylation. Important amongst such mechanisms may be cross-reactivity between environmental and endogenous carbohydrate epitopes. It will be interesting to see if future research supports the idea that groups of diseases (e. g., rheumatoid arthritis, tuberculosis, Crohn's) are indeed related by a common aetiopathogenesis [i. e., G(0)].