Kupffer cells have suppressive function for liver metastasis formation of colon cancer in early stage.
Kupffer cells have suppressive function for liver metastasis formation of colon cancer in early stage.
复制标题
库普弗细胞对早期结肠癌肝转移形成具有抑制作用。
DOI：
10.11378/organbio.22.184
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
大河内信弘.
中科院分区：
文献类型：
--
作者：
松村英樹;近藤匡;小川光一;田村孝史;福永潔;大河内信弘.
本研究采用Kupff er细胞（KCs）作为靶细胞，观察KCs在肝转移中的作用。提示KCs在肝转移早期具有抑制作用。此外，我们使用活体显微镜（IVM）来分析结肠癌肝转移中KC和TC的正弦动力学。IVM显示TC注射后早期即开始粘附于KC上。KC吞噬TC，TC与KC粘附。提示KC在肝转移早期对TC的吞噬作用强烈地抑制了此后肝转移结节的形成。
In this study, to clarify the role of Kupff er cells (KCs) in the liver metastasis, we eliminated KCs at diff erent time points before or after injection of tumor cells (TCs). Our results suggested that the role of KCs was suppressive especially in the early stage of liver metastasis. In addition, we used intravital microscopy (IVM) to analyze the sinusoidal dynamics of both KCs and TCs in colon cancer metastasis to the liver. IVM showed that TCs adhered to KCs from the early time after TC injection. The KCs phagocytosed the TCs, which adhered with the KCs. It is suggested that KC phagocytosis of TCs in the early stage of liver metastasis strongly suppressed the formation of the liver metastatic nodules thereafter.