Prognostic Impact of Immune-Related Gene Expression in Preoperative Peripheral Blood from Gastric Cancer Patients
Prognostic Impact of Immune-Related Gene Expression in Preoperative Peripheral Blood from Gastric Cancer Patients
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DOI：
10.1245/s10434-018-6739-4
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发表时间：
2018-11-01
影响因子：
3.7
通讯作者：
Mimori, Koshi
中科院分区：
文献类型：
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作者：
Ito, Shuhei;Fukagawa, Takeo;Mimori, Koshi
背景：抗PD-1治疗在胃癌(GC)中显示出良好的临床疗效。方法采用定量RT-PCR方法检测372例胃癌患者术前外周血中PD-1、PD-L1和CD8的表达水平，并分析其与患者生存期等临床病理因素的关系。结果胃癌患者外周血中PD-1、PD-L1、CD8基因表达水平明显高于正常对照组(均P
BackgroundAnti-PD-1 therapy has shown a promising clinical outcome in gastric cancer (GC). We evaluated the clinical significance of systemic immune-related gene expression in GC patients who underwent surgery.MethodsThe correlation between the preoperative PD-1, PD-L1, and CD8 mRNA levels in peripheral blood (PB) and clinicopathological factors, including survival, in 372 GC patients was evaluated using quantitative RT-PCR. PD-1- and PD-L1-expressing cells were identified by flow cytometric analysis.ResultsThe PD-1, PD-L1, and CD8 mRNA levels in GC patients were significantly higher than those in normal controls, respectively (all P