β-glucan: Crucial component of the fungal cell wall and elusive MAMP in plants
β-glucan: Crucial component of the fungal cell wall and elusive MAMP in plants
复制标题
DOI：
10.1016/j.fgb.2015.12.004
复制
发表时间：
2016-05-01
影响因子：
3
通讯作者：
Zuccaro, Alga
中科院分区：
文献类型：
--
作者：
Fesel, Philipp H.;Zuccaro, Alga
植物的先天免疫首先依赖于对入侵微生物的检测。因此，植物进化出受体来感知微生物的独特分子，即所谓的微生物相关分子模式或MAMP。研究最多的真菌MamP是几丁质，它是真菌细胞壁的重要结构构件。在过去的几年里，几种植物对甲壳素的受体已经被表征，以及真菌为逃避甲壳素识别而采取的不同策略。尽管甲壳素作为植物防御的激发子具有很强的活性，但与其他复合糖相比，它只占大多数真菌细胞壁的一小部分。β-葡聚糖是真菌细胞壁中含量最丰富的一种多糖，也是一种MAMP，但在植物中对β-葡聚糖的感知和信号转导机制尚不清楚。相比之下，β-葡聚糖的识别和信号机制在哺乳动物中表现得很好。C型凝集素受体Dectin-1是这些机制的关键组成部分。在这篇综述中，我们描述了关于植物中至少存在一种β-葡聚糖受体的有价值的知识，以及关于β-葡聚糖研究的障碍。此外，我们还讨论了未来葡聚糖研究的可能前景，以及将收集到的知识从哺乳动物系统转移到植物的可能性。(C)2015年提交人。由爱思唯尔公司出版。
Plant innate immunity relies in first place on the detection of invading microbes. Thus, plants evolved receptors to sense unique molecules of the microbe, the so called microbe-associated molecular patterns or MAMPs. The best studied fungal MAMP is chitin, an important structural building block of the fungal cell wall. Over the past years several plant receptors for chitin have been characterized as well as different strategies adopted by fungi to evade chitin recognition. Despite its strong activity as an elicitor of plant defense chitin represents only a small percentage of the cell wall of most fungi compared to other complex sugars. beta-glucan, the most abundant fungal cell wall polysaccharide, also serves as a MAMP, but the mechanisms of beta-glucan perception and signaling in plants are largely unknown. In contrast to that the beta-glucan recognition and signaling machineries are well characterized in mammals. The C-type lectin receptor Dectin-1 is a key component of these machineries. In this review we describe valuable knowledge about the existence of at least one beta-glucan receptor in plants and about the hindrances in beta-glucan research. Additionally we discuss possible future perspectives of glucan research and the possibility to transfer the gathered knowledge from mammalian systems to plants. (C) 2015 The Authors. Published by Elsevier Inc.