KNOW-KT (KoreaN cohort study for outcome in patients with kidney transplantation: a 9-year longitudinal cohort study): study rationale and methodology
KNOW-KT (KoreaN cohort study for outcome in patients with kidney transplantation: a 9-year longitudinal cohort study): study rationale and methodology
复制标题
DOI：
10.1186/1471-2369-15-77
复制
发表时间：
2014-05-09
期刊：
影响因子：
2.3
通讯作者：
Ahn, Curie
中科院分区：
文献类型：
--
作者：
Yang, Jaeseok;Lee, Joongyup;Ahn, Curie
背景：与其他种族相比，接受肾移植(KT)的亚洲患者通常有更好的移植肾存活率和更低的心血管疾病负担。KNOW-KT旨在探讨韩国KT患者的同种异体移植物存活率、心血管事件和代谢特征，并阐明危险因素。方法：KNOW-KT是一项包括韩国8个移植中心的多中心观察性队列研究。KNOW-KT将在2012至2015年间招募1000名KT获得者，并对他们进行长达9年的跟踪。在KT时，以预先指定的间隔，将记录关于心血管疾病和代谢并发症的临床信息、实验室测试结果以及功能和成像研究。并存状态将通过年龄调整的Charlson并存指数进行评估。将定期监测服药依从性和生活质量(QOL)信息。生活质量将通过肾脏疾病生活质量简表进行评估。捐赠者将包括在世捐赠者和已故捐赠者，他们的状况将通过肾脏捐赠者风险指数进行评估。主要终点包括移植物丢失和患者死亡率。次要终点包括肾功能恶化(EGFR减少到
Background: Asian patients undergoing kidney transplantation (KT) generally have better renal allograft survival and a lower burden of cardiovascular disease than those of other racial groups. The KNOW KT aims to explore allograft survival rate, cardiovascular events, and metabolic profiles and to elucidate the risk factors in Korean KT patients.Methods: KNOW-KT is a multicenter, observational cohort study encompassing 8 transplant centers in the Republic of Korea. KNOW-KT will enroll 1,000 KT recipients between 2012 and 2015 and follow them up to 9 years. At the time of KT and at pre-specified intervals, clinical information, laboratory test results, and functional and imaging studies on cardiovascular disease and metabolic complications will be recorded. Comorbid status will be assessed by the age-adjusted Charlson co-morbidity index. Medication adherence and information on quality of life (QoL) will be monitored periodically. The QoL will be assessed by the Kidney Disease Quality of Life Short Form. Donors will include both living donors and deceased donors whose status will be assessed by the Kidney Donor Risk Index. Primary endpoints include graft loss and patient mortality. Secondary endpoints include renal functional deterioration (a decrease in eGFR to