A dosimetric evaluation of knowledge-based VMAT planning with simultaneous integrated boosting for rectal cancer patients.
A dosimetric evaluation of knowledge-based VMAT planning with simultaneous integrated boosting for rectal cancer patients.
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DOI：
10.1120/jacmp.v17i6.6410
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发表时间：
2016-11-08
影响因子：
2.1
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Wu H;Jiang F;Yue H;Li S;Zhang Y
RapidPlan是一种基于知识的商业优化器，已在头颈癌、肺癌、食道癌、乳腺癌、肝癌和前列腺癌患者中进行了测试。为了评估其在直肠癌VMAT计划与同步整合加强（SIB）方面的性能，本研究配置了一个DVH（剂量体积直方图）估计模型，该模型由80个此类尽力而为的手动病例组成。使用模型生成的物镜，重新优化了其他70个临床批准计划的MLC（多叶准直器）序列，同时保留了剩余参数，如射野几何形状和光子能量。通过比较均匀性指数（HI）、适形指数（CI）、热点（接受处方剂量的107%以上的体积）、平均剂量和剂量与股骨头（和）和膀胱（和）的50%体积以及平均DVH绘图来评估剂量测定结局。配对样本t检验或Wilcoxon符号秩检验表明，RapidPlan（用于和用于PTV）和原始计划（用于和用于PTV）分别获得了相当的CI。RapidPlan病例（用于和用于PTV）的计划靶体积和PTV的HI比原始计划（用于和用于PTV）略有改善。在原始计划中发现的阳性病例（18例）多于RapidPlan组（0例）。RapidPlan分别显著减少了（从到）、（从到G）、（从到）和（从到）。RapidPlan数据点的分布更加集中，表明计划质量的一致性增强。PACS编号：87.55.de; 87.55.dk
RapidPlan, a commercial knowledge‐based optimizer, has been tested on head and neck, lung, esophageal, breast, liver, and prostate cancer patients. To appraise its performance on VMAT planning with simultaneous integrated boosting (SIB) for rectal cancer, this study configured a DVH (dose‐volume histogram) estimation model consisting 80 best‐effort manual cases of this type. Using the model‐ generated objectives, the MLC (multileaf collimator) sequences of other 70 clinically approved plans were reoptimized, while the remaining parameters, such as field geometry and photon energy, were maintained. Dosimetric outcomes were assessed by comparing homogeneity index (HI), conformal index (CI), hot spots (volumes receiving over 107% of the prescribed dose, ), mean dose and dose to the 50% volume of femoral head ( and ), and urinary bladder ( and ), and the mean DVH plotting. Paired samples t‐test or Wilcoxon signed‐rank test suggested that comparable CI were achieved by RapidPlan ( for , and for PTV) and original plans ( for and for PTV), respectively . Slightly improved HI of planning target volume and PTV were observed in the RapidPlan cases ( for , and for PTV) than the original plans ( for and for PTV), . More cases with positive were found in the original (18 plans) than the RapidPlan group (none). RapidPlan significantly reduced the (by from to ), (by from to G), (by from to ), and (by from to ), respectively. The more concentrated distribution of RapidPlan data points indicated an enhanced consistency of plan quality. PACS number(s): 87.55.de; 87.55.dk
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影响因子：
3.8
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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期刊：
Radiation oncology (London, England)
影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.ijrobp.2014.11.014
发表时间：
2015-03-01
影响因子：
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作者：
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