End-systolic measures of regional ventricular performance.
End-systolic measures of regional ventricular performance.
复制标题
局部心室性能的收缩末期测量。
DOI：
10.1161/01.cir.73.5.938
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发表时间：
1986
期刊：
影响因子：
37.8
通讯作者：
Becker,LC
中科院分区：
文献类型：
--
作者：
Aversano,T;Maughan,WL;Hunter,WC;Kass,D;Becker,LC
局部心室功能的尺寸变化测量，如绝对或百分比壁增厚（Δ T或% Δ T）或节段缩短（Δ L或% Δ L），是高度负荷依赖性的。在16只麻醉的杂种狗中，我们评估了收缩末期压力-厚度和收缩末期压力-长度关系（ESPTR，ESPLR）作为区域功能的更多负荷独立性测量方法的使用。我们发现，ESPTR和ESPLR可以在没有可检测到的压力感受器介导的反射变化的心脏收缩状态下测量。多巴酚丁胺的全身给药使ESPTR向右移动，使ESPLR向左移动，这主要是由于斜率（Ees）的变化。Δ T，% Δ T和Δ L，% Δ L均未检测到多巴酚丁胺的正性肌力作用，因为前负荷降低。普萘洛尔全身给药后，ESPTR、ESPLR、Δ T、% Δ T和Δ L、% Δ L检测到负性肌力作用。因此，全身性普萘洛尔使对照组的ESPTR向左移动，使ESPLR向右移动，主要是由于Ees的变化。多巴酚丁胺的区域给药使ESPTR和ESPLR向接受药物的区域正收缩力的方向移动，而简单的局部功能尺寸变化测量未能检测到变力作用，因为前负荷下降并且局部收缩末期的时间发生了变化。改变。与区域普萘洛尔ESPTR，ESPLR和简单的尺寸变化措施检测负性肌力作用。因此，ESPTR、ESPLR是局部心室功能的可靠测量，并且可能优于局部功能的简单尺寸变化测量，特别是当负荷条件或局部收缩的定时通过干预改变时。
Dimension change measures of regional ventricular function, such as absolute or percent wall thickening (delta T or % delta T) or segmental shortening (delta L or % delta L), are highly load dependent. In 16 anesthetized mongrel dogs we assessed use of the end-systolic pressure-thickness and end-systolic pressure-length relationships (ESPTR, ESPLR) as more load-independent measures of regional function. We found that the ESPTR and ESPLR could be measured without detectable baroreceptor-mediated reflex changes in cardiac contractile state. Systemic administration of dobutamine shifted the ESPTR to the right and the ESPLR to the left of control, mainly due to a change in the slope (Ees) of the relationships. Both delta T, % delta T and delta L, % delta L failed to detect the positive inotropic effect of dobutamine because of an associated reduction in preload. With systemic administration of propranolol, ESPTR, ESPLR, delta T, % delta T, and delta L, % delta L detected the negative inotropic effect. Thus systemic propranolol shifted the ESPTR to the left and the ESPLR to the right of control, mainly due to a change in Ees. Regional administration of dobutamine shifted the ESPTR and the ESPLR in the direction of positive contractility in the region receiving the drug, whereas simple dimension change measures of regional function failed to detect the inotropic effect because preload fell and the timing of regional end-systole was altered. With regional propranolol both the ESPTR, ESPLR and simple dimension change measures detected the negative inotropic effect. Thus the ESPTR, ESPLR is a reliable measure of regional ventricular function and may be better than simple dimension change measures of regional function, particularly when loading conditions or the timing of regional systole is altered by an intervention.