The aminopyrine breath test does not correlate with histologic disease severity in patients with cholestasis.
The aminopyrine breath test does not correlate with histologic disease severity in patients with cholestasis.
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氨基比林呼气试验与胆汁淤积患者的组织学疾病严重程度无关。
DOI：
10.1002/hep.1840070309
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Schoeller,DA
中科院分区：
文献类型：
--
作者：
Baker,AL;Krager,PS;Kotake,AN;Schoeller,DA
为了确定氨基比林呼气试验是否可用于记录胆汁淤积性肝病患者的肝硬化，19例患者（13例原发性胆汁性肝硬化，4例硬化性胆管炎和2例慢性肝外胆管梗阻）进行了临床和生化评价，肝活检和氨基比林呼气试验。结果与10例活检证实的慢性活动性肝炎伴桥接和/或肝硬化患者和22例健康受试者进行了比较。10例肝硬化胆汁淤积患者的氨基比林呼气试验结果与胆汁淤积患者（平均值±SD，11.2±5.0 vs. 11.6±2.8%剂量/2小时，p< 0.05）或健康受试者（11.5±2.9%剂量/2小时）的结果无显著差异。相反，慢性肝炎患者的结果明显降低（3.2±1.9%剂量/2小时，p< 0.05）。胆汁淤积患者的氨基比林呼气试验结果与常规肝功能检查结果无相关性。这些结果表明，氨基比林呼气试验在临床上识别胆汁淤积性肝病患者肝硬化的存在是没有用的，并提供了进一步的证据，减少微粒体酶功能是胆汁淤积性肝病的晚期特征。
To determine whether the aminopyrine breath test can be used to document the presence of cirrhosis in patients with cholestatic liver disease, 19 patients (13 primary biliary cirrhosis, 4 sclerosing cholangitis and 2 chronic extrahepatic bile duct obstruction) underwent clinical and biochemical evaluations, liver biopsies and an aminopyrine breath test. Results were compared with those in 10 patients with biopsy-proven chronic active hepatitis with bridging and/or cirrhosis and in 22 healthy subjects. The aminopyrine breath test results in the 10 cholestatic patients with cirrhosis were not significantly different from the results in precirrhotic cholestatic patients (mean±SD, 11.2±5.0 vs. 11.6±2.8% dose per 2 hr, p< 0.05) or healthy subjects (11.5±2.9% dose per 2 hr). In contrast, the results in the patients with chronic hepatitis were markedly depressed (3.2±1.9% dose per 2 hr, p< 0.05). The aminopyrine breath test results did not correlate with results of conventional liver function tests in the cholestatic patients. These results demonstrate that the aminopyrine breath test is not clinically useful in identifying the presence of cirrhosis in patients with cholestatic liver disease, and provide further evidence that decreased microsomal enzyme function is a late feature of cholestatic liver disease.