Synthesis of double-13C-labeled imidazole derivatives
Synthesis of double-13C-labeled imidazole derivatives
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DOI：
10.1016/j.tetlet.2018.07.048
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发表时间：
2018-09-26
影响因子：
1.8
通讯作者：
Kan, Toshiyuki
中科院分区：
文献类型：
--
作者：
Ouchi, Hitoshi;Asakawa, Tomohiro;Kan, Toshiyuki
以稳定同位素标记的氰化钠和原甲酸三乙酯为原料，合成了双C-13标记的咪唑-4-甲酰胺(ICA：C-13(2)-1)和5-aminoimidazole-4-carboxamide-1-beta-riboside(AICAR：C-13(2)-5)。关键中间体4-氨基咪唑-5-甲酰胺(AICA：C-13(2)-4)也可以通过已报道的方法获得双C-13标记的组氨酸和腺苷衍生物。(C)2018爱思唯尔有限公司。保留所有权利。
Double-C-13-labeled imidazole-4-carboxamide (ICA: C-13(2)-1) and 5-aminoimidazole-4-carboxamide-1-beta-riboside (AICAr: C-13(2)-5) were synthesized from stable isotope-labeled sodium cyanide and triethyl ortho-formate. The key intermediate, 4-aminoimidazole-5-carboxamide (AICA: C-13(2)-4), should also provide access to double-C-13-labeled histidine and adenosine derivatives via reported methods. (C) 2018 Elsevier Ltd. All rights reserved.