Type 1 adenylyl cyclase is essential for maintenance of remote contextual fear memory.
Type 1 adenylyl cyclase is essential for maintenance of remote contextual fear memory.
复制标题
DOI：
10.1523/jneurosci.2413-08.2008
复制
发表时间：
2008-11-26
期刊：
影响因子：
--
通讯作者：
Storm DR
中科院分区：
文献类型：
--
作者：
Shan Q;Chan GC;Storm DR
虽然海马体依赖记忆的分子机制已经被广泛研究，但对远程记忆重要的信号事件知之甚少。在这里，我们报告了缺乏1型腺苷环化酶(AC1)的小鼠能够建立和提取远程背景记忆，但不能像野生型小鼠那样维持这种记忆。有趣的是，过度表达AC1的小鼠表现出优越的远程情境记忆，尽管它们表现出正常的海马体依赖的情境记忆。这些数据表明，钙与cAMP偶联有助于远程记忆的稳定性，并确认AC1是改善长期远程记忆的潜在药物靶点。
Although molecular mechanisms for hippocampus-dependent memory have been extensively studied, much less is known about signaling events important for remote memory. Here we report that mice lacking type 1 adenylyl cyclase (AC1) are able to establish and retrieve remote contextual memory but unable to sustain it as long as wild type mice. Interestingly, mice over-expressing AC1 show superior remote contextual memory even though they exhibit normal hippocampus-dependent contextual memory. These data illustrate that calcium coupling to cAMP contributes to the stability of remote memory and identifies AC1 as a potential drug target site to improve long-term remote memory.