Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites
Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites
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DOI：
10.1152/jn.2001.86.6.2998
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发表时间：
2001-12-01
影响因子：
2.5
通讯作者：
Spruston, N
中科院分区：
文献类型：
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作者：
Golding, NL;Kath, WL;Spruston, N
在海马CA1锥体神经元中，动作电位通常在轴突中起始并反向传播到树突中，形成突触活动的整合并影响突触可塑性的诱导。尽管以前的报告描述的动作电位传播的近端顶端树突，在何种程度上动作电位侵入远端树突的CA1锥体神经元仍然存在争议。使用成对的体细胞和树突全细胞记录，我们发现在距离索马280 μ m的树突中，单个反向传播动作电位表现出
In hippocampal CA1 pyramidal neurons, action potentials are typically initiated in the axon and backpropagate into the dendrites, shaping the integration of synaptic activity and influencing the induction of synaptic plasticity. Despite previous reports describing action-potential propagation in the proximal apical dendrites, the extent to which action potentials invade the distal dendrites of CA1 pyramidal neurons remains controversial. Using paired somatic and dendritic whole cell recordings, we find that in the dendrites proximal to 280 mum from the soma, single backpropagating action potentials exhibit