Strategic directions in tissue engineering
Strategic directions in tissue engineering
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DOI：
10.1089/ten.2007.0335
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发表时间：
2007-12-01
影响因子：
--
通讯作者：
Jansen, John A.
中科院分区：
文献类型：
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作者：
Johnson, Peter C.;Mikos, Antonios G.;Jansen, John A.
组织工程领域发展迅速。鉴于其对临床护理的终极重要性，现在是评估该领域战略方向以优化研发活动的恰当时机。为了明确组织工程的战略方向，提出了一个长远但可实现的临床目标，并对全球24位组织工程领域的领军人物进行了系统的咨询，以确定实现该目标的最佳途径。通过使用改良的方针管理流程，我们确定了14个关键活动类别，然后根据其对该领域的紧迫优先级对它们进行了分层。分析结果表明，一系列高度相互依赖的活动主要受对血管生成、干细胞科学的理解需求以及利用分子生物学和系统生物学工具以更深入理解组织发育和调控的需求所主导。
The field of tissue engineering is developing rapidly. Given its ultimate importance to clinical care, the time is appropriate to assess the field's strategic directions to optimize research and development activities. To characterize strategic directions in tissue engineering, a distant but reachable clinical goal was proposed and a worldwide body of 24 leaders in tissue engineering was queried systematically to determine the best paths toward that goal. Using a modified Hoshin process, we identified 14 critical activity categories and then stratified them by their immediate priority for the field. The result of the analysis illustrates a highly interdependent set of activities that are dominated by the need for an understanding of angiogenesis, stem cell science, and the utilization of molecular biology and systems biology tools to enable a deeper comprehension of tissue development and control.