Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides.
Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides.
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DOI：
10.1073/pnas.87.19.7517
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发表时间：
1990-10
影响因子：
11.1
通讯作者：
K. L. Rock;L. Rothstein;S. Gamble;B. Benacerraf
中科院分区：
文献类型：
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作者：
K. L. Rock;L. Rothstein;S. Gamble;B. Benacerraf
T淋巴细胞识别与主要组织相容性复合体（MHC）编码分子相关的内源性产生的抗原肽。来自细胞外液的肽可以与I类和II类MHC分子结合展示。在这里，我们报告说，成熟的Kb I类MHC分子结合肽后，其轻链的解离和重新结合。与II类MHC分子不同，完整的Kb异二聚体相对不接受结合肽。这种特性可以保持I类和II类MHC限制性肽的分离，并对肽作为疫苗的使用具有影响。
T lymphocytes recognize endogenously produced antigenic peptides in association with major histocompatibility complex (MHC)-encoded molecules. Peptides from the extracellular fluid can be displayed in association with class I and class II MHC molecules. Here we report that mature Kb class I MHC molecules bind peptides upon dissociation and reassociation of their light chain. Intact Kb heterodimers, unlike class II MHC molecules, are relatively unreceptive to binding peptides. This property may maintain segregation of class I and class II MHC-restricted peptides and has implications for the use of peptides as vaccines.