Spontaneous remission of spasms in West syndrome - implications of viral infection
Spontaneous remission of spasms in West syndrome - implications of viral infection
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DOI：
10.1016/s0387-7604(01)00278-9
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发表时间：
2001-11-01
影响因子：
1.7
通讯作者：
Hattori, H
中科院分区：
文献类型：
--
作者：
Hattori, H
在1970年至2000年间的日本医学文献数据库中，有29名韦斯特综合征患者表现出自发缓解。在25/29(86%)的患者中，自发缓解前有病毒感染，其中以皮疹为主。其中16/29(55%)的痉挛在中位数2个月后复发。然而，剩下的一些婴儿痉挛得到了持久的缓解。病毒感染和自发缓解之间的这种联系表明，免疫炎症过程是某些患者韦斯特综合征的基础。更好地了解这些机制可能会导致一种新的治疗西方综合征的方法。(C)2001 Elsevier Science B.V.保留所有权利。
On a database of the Japanese medical literature between 1970 and 2000, there were 29 patients with West syndrome showing spontaneous remission. In 25/29 (86%) of the patients, spontaneous remission was preceded by viral infections, among which exanthema subitum predominated. In 16/29 (55%), the spasms recurred a median of 2 months later. However, some of the remaining infants attained lasting remission of the spasms. This link between viral infections and spontaneous remission suggests immuno-inflammatory processes underlie West syndrome in certain patients. Better understanding of such mechanisms may lead to a new therapeutic approach to West syndrome. (C) 2001 Elsevier Science B.V. All rights reserved.