Theranostics in the gut
Theranostics in the gut
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肠道治疗诊断学
DOI：
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
S. Cochran
中科院分区：
文献类型：
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作者：
F. Stewart;H. Mulvana;I. Näthke;S. Cochran
作为身体的一部分，被认为是外部的，胃肠道（GI）应该允许容易进入，但它仍然相对模糊，特别是小肠，直到视频胶囊式内窥镜（VCE）出现在过去的20年中，唯一能够常规查看整个长度。此外，VCE还借鉴了电子设备、无线通信和高效电力输送等当代主题，为未来设备提供了一个模型。然而，治疗性胶囊式内窥镜（TCE）的研究有限，且与诊断结合不佳。本章回顾了相关进展，强调超声（美国）对GI TCE特别有希望。描述了不同长度尺度的胃肠道，包括从口腔到肛门的共同的多层结构及其在细胞和亚细胞水平上的变化。描述了多模式胶囊式内窥镜的最新发展，包括用于组织内成像的US，以及TCE的靶向药物递送（TDD），特别是US介导，因为与更简单的消融技术相关的潜在穿孔。这是一个概念验证的治疗诊断设备的例子，该设备有可能治疗炎症性肠病和结肠癌等疾病。最后，随着未来的重大发展，强调了相关领域，包括进一步的胶囊开发和纳米技术。
As a part of the body that is considered external, the gastrointestinal (GI) tract should allow easy access, but it remained relatively obscure, particularly the small intestine, until video capsule endoscopy (VCE) emerged in the past 20 years, uniquely able to view the entire length routinely. Additionally, drawing on contemporary topics including miniaturisation of electronics, wireless communications and efficient electrical power delivery, VCE provides a model for future devices. However, research in therapeutic capsule endoscopy (TCE) has been limited and poorly integrated with diagnostics. This chapter reviews relevant progress, highlighting ultrasound (US) as particularly promising for GI TCE. A description of the GI tract at different length scales is given, including the common, multi-layered structure maintained from mouth to anus and its variation down to cellular and sub-cellular level. Recent developments in multimodal capsule endoscopy are described, including US for imaging within tissue, and targeted drug delivery (TDD) is highlighted for TCE, particularly with US-mediation, because of the potential perforation associated with simpler ablation techniques. This is exemplified by a proof-of-concept theranostic device with the potential to treat conditions such as inflammatory bowel disease and colon cancer. Finally, with significant development ahead, relevant areas are highlighted, including further capsule development and nanotechnology.